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Vibrio parahaemolyticus inhibits Rho...

Casselli, Timothy Richard.

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Vibrio parahaemolyticus inhibits Rho-family GTPase activation via the chromosome 1 type three secreted effector Vp1686.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Vibrio parahaemolyticus inhibits Rho-family GTPase activation via the chromosome 1 type three secreted effector Vp1686./
作者:	Casselli, Timothy Richard.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2008,
面頁冊數:	192 p.
附註:	Source: Masters Abstracts International, Volume: 47-03, page: 1499.
Contained By:	Masters Abstracts International47-03.
標題:	Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR44577
ISBN:	9780494445778

Vibrio parahaemolyticus inhibits Rho-family GTPase activation via the chromosome 1 type three secreted effector Vp1686.
Casselli, Timothy Richard.

Vibrio parahaemolyticus inhibits Rho-family GTPase activation via the chromosome 1 type three secreted effector Vp1686. - Ann Arbor : ProQuest Dissertations & Theses, 2008 - 192 p.

Source: Masters Abstracts International, Volume: 47-03, page: 1499.

Thesis (M.Sc.)--University of Calgary (Canada), 2008.

Vibrio parahaemolyticus is a leading cause of seafood borne gastroenteritis, however its virulence mechanisms are not well understood. The ability of North American isolates of V. parahaemolyticus to inhibit Rho-family GTPases was examined in cultured HeLa cells and macrophages. Intracellular Rho activation was inhibited in response to external stimuli after infection with clinical and environmental isolates. In vitro activation of Rho, Rac, and Cdc42 isolated from infected cell lysates was also inhibited, indicating that the bacteria were specifically targeting GTPase activation. GTPase inhibition was dependent on translocation of the effector Vp1686 by the chromosome I type three secretion system (T3SS), despite a lack of sequence homology between Vp1686 and known GTPase inhibiting proteins. The ability to inhibit Rho-family GTPases was independent of other virulence factors including the chromosome II T3SS and the haemolytic toxins. The findings reported here contribute to the understanding of virulence mechanisms used by V. parahaemolyticus.

ISBN: 9780494445778Subjects--Topical Terms:

536250
Microbiology.

Vibrio parahaemolyticus inhibits Rho-family GTPase activation via the chromosome 1 type three secreted effector Vp1686.
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