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Bone toxicology

Smith, Susan Y.

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Bone toxicology

Record Type:	Electronic resources : Monograph/item
Title/Author:	Bone toxicology/ edited by Susan Y. Smith, Aurore Varela, Rana Samadfam.
other author:	Smith, Susan Y.
Published:	Cham :Springer International Publishing : : 2017.,
Description:	xii, 474 p. :ill., digital ;24 cm.
[NT 15003449]:	Bone Toxicology in Preclinical Drug Testing -- Bone Physiology and Biology -- Study designs and Regulatory Considerations -- Specific Considerations for Bone Evaluations for Pediatric Therapeutics -- Bone Pharmacology and other models in Preclinical Drug Testing -- Methods in Bone Toxicology -- Biochemical Markers and Hormones -- Imaging -- Biomechanics -- Pathology and Histomorphometry -- Integrated System Toxicology -- Bone and Muscle -- Bone and Reproductive System -- Bone and Kidneys -- Bone and Energy Metabolism -- Bone and Immune System -- Bone and Central Nervous System -- Bone and Other Organs.
Contained By:	Springer eBooks
Subject:	Toxicology. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-56192-9
ISBN:	9783319561929

Bone toxicology
Bone toxicology[electronic resource] /edited by Susan Y. Smith, Aurore Varela, Rana Samadfam. - Cham :Springer International Publishing :2017. - xii, 474 p. :ill., digital ;24 cm. - Molecular and integrative toxicology,2168-4219. - Molecular and integrative toxicology..

Bone Toxicology in Preclinical Drug Testing -- Bone Physiology and Biology -- Study designs and Regulatory Considerations -- Specific Considerations for Bone Evaluations for Pediatric Therapeutics -- Bone Pharmacology and other models in Preclinical Drug Testing -- Methods in Bone Toxicology -- Biochemical Markers and Hormones -- Imaging -- Biomechanics -- Pathology and Histomorphometry -- Integrated System Toxicology -- Bone and Muscle -- Bone and Reproductive System -- Bone and Kidneys -- Bone and Energy Metabolism -- Bone and Immune System -- Bone and Central Nervous System -- Bone and Other Organs.

The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.

ISBN: 9783319561929

Standard No.: 10.1007/978-3-319-56192-9doiSubjects--Topical Terms:

556884
Toxicology.

LC Class. No.: RA1211

Dewey Class. No.: 615.9

Bone toxicology
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260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2017.
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490 1 $a Molecular and integrative toxicology, $x 2168-4219
505 0 $a Bone Toxicology in Preclinical Drug Testing -- Bone Physiology and Biology -- Study designs and Regulatory Considerations -- Specific Considerations for Bone Evaluations for Pediatric Therapeutics -- Bone Pharmacology and other models in Preclinical Drug Testing -- Methods in Bone Toxicology -- Biochemical Markers and Hormones -- Imaging -- Biomechanics -- Pathology and Histomorphometry -- Integrated System Toxicology -- Bone and Muscle -- Bone and Reproductive System -- Bone and Kidneys -- Bone and Energy Metabolism -- Bone and Immune System -- Bone and Central Nervous System -- Bone and Other Organs.
520 $a The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.
650 0 $a Toxicology. $3 556884
650 0 $a Bones. $3 634311
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650 2 4 $a Animal Models. $3 1001014
700 1 $a Smith, Susan Y. $3 3258456
700 1 $a Varela, Aurore. $3 3258457
700 1 $a Samadfam, Rana. $3 3258458
710 2 $a SpringerLink (Online service) $3 836513
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830 0 $a Molecular and integrative toxicology. $3 2058495
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-56192-9
950 $a Biomedical and Life Sciences (Springer-11642)