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Safety and efficacy of gene-based th...

Brunetti-Pierri, Nicola.

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Safety and efficacy of gene-based therapeutics for inherited disorders

Record Type:	Electronic resources : Monograph/item
Title/Author:	Safety and efficacy of gene-based therapeutics for inherited disorders/ edited by Nicola Brunetti-Pierri.
other author:	Brunetti-Pierri, Nicola.
Published:	Cham :Springer International Publishing : : 2017.,
Description:	ix, 220 p. :ill., digital ;24 cm.
[NT 15003449]:	Overview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors.
Contained By:	Springer eBooks
Subject:	Genetic disorders - Gene therapy. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-53457-2
ISBN:	9783319534572

Safety and efficacy of gene-based therapeutics for inherited disorders
Safety and efficacy of gene-based therapeutics for inherited disorders[electronic resource] /edited by Nicola Brunetti-Pierri. - Cham :Springer International Publishing :2017. - ix, 220 p. :ill., digital ;24 cm.

Overview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors.

In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers, toxicologists, pharmacologists, molecular biologists, physicians, and students in these fields.

ISBN: 9783319534572

Standard No.: 10.1007/978-3-319-53457-2doiSubjects--Topical Terms:

3241593
Genetic disorders
--Gene therapy.

LC Class. No.: RB155.8

Dewey Class. No.: 616.042

Safety and efficacy of gene-based therapeutics for inherited disorders
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245 0 0 $a Safety and efficacy of gene-based therapeutics for inherited disorders $h [electronic resource] / $c edited by Nicola Brunetti-Pierri.
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300 $a ix, 220 p. : $b ill., digital ; $c 24 cm.
505 0 $a Overview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors.
520 $a In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers, toxicologists, pharmacologists, molecular biologists, physicians, and students in these fields.
650 0 $a Genetic disorders $x Gene therapy. $3 3241593
650 0 $a Genetic transformation. $3 682697
650 1 4 $a Biomedicine. $3 890831
650 2 4 $a Pharmacology/Toxicology. $3 890953
650 2 4 $a Gene Therapy. $3 600618
650 2 4 $a Molecular Medicine. $3 890952
700 1 $a Brunetti-Pierri, Nicola. $3 3241592
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856 4 0 $u http://dx.doi.org/10.1007/978-3-319-53457-2
950 $a Biomedical and Life Sciences (Springer-11642)