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Plasmodium's Crossroads: Deciphering...

Goldowitz, Ilana Sarah.

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Plasmodium's Crossroads: Deciphering the Molecular Pathway that Leads to Malaria Transmission.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Plasmodium's Crossroads: Deciphering the Molecular Pathway that Leads to Malaria Transmission./
Author:	Goldowitz, Ilana Sarah.
Description:	167 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.
Contained By:	Dissertation Abstracts International77-04B(E).
Subject:	Parasitology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3738787
ISBN:	9781339292762

Plasmodium's Crossroads: Deciphering the Molecular Pathway that Leads to Malaria Transmission.
Goldowitz, Ilana Sarah.

Plasmodium's Crossroads: Deciphering the Molecular Pathway that Leads to Malaria Transmission. - 167 p.

Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.

Thesis (Ph.D.)--Harvard University, 2015.

Plasmodium falciparum is the causative agent of the most severe form of malaria. Transmission from humans to mosquito vectors is an essential step in this eukaryotic parasite's life cycle and in the spread of malaria disease, which killed nearly 600,000 people in 2013. I investigated the developmental switch parasites make to the transmission stage or gametocyte, with the goal of identifying molecular mechanisms and environmental triggers of gametocyte formation. In Chapter 2 of this dissertation, I discuss the completion of a genetic mutagenesis screen leading to the discovery of a putative E3 ubiquitin ligase enzyme which is likely a negative regulator of gametocyte formation. Chapter 3 presents findings on population-based regulation of gametocyte production and on parasite-derived microvesicles that transfer between cells and stimulate gametocyte production. In Chapter 4, I and coauthors present a protocol for measuring parasite growth and gametocyte production in response to drugs or other treatments.

ISBN: 9781339292762Subjects--Topical Terms:

635062
Parasitology.

Plasmodium's Crossroads: Deciphering the Molecular Pathway that Leads to Malaria Transmission.
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100 1 $a Goldowitz, Ilana Sarah. $3 3193175
245 1 0 $a Plasmodium's Crossroads: Deciphering the Molecular Pathway that Leads to Malaria Transmission.
300 $a 167 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.
500 $a Advisers: Matthias Marti; Jon Clardy.
502 $a Thesis (Ph.D.)--Harvard University, 2015.
520 $a Plasmodium falciparum is the causative agent of the most severe form of malaria. Transmission from humans to mosquito vectors is an essential step in this eukaryotic parasite's life cycle and in the spread of malaria disease, which killed nearly 600,000 people in 2013. I investigated the developmental switch parasites make to the transmission stage or gametocyte, with the goal of identifying molecular mechanisms and environmental triggers of gametocyte formation. In Chapter 2 of this dissertation, I discuss the completion of a genetic mutagenesis screen leading to the discovery of a putative E3 ubiquitin ligase enzyme which is likely a negative regulator of gametocyte formation. Chapter 3 presents findings on population-based regulation of gametocyte production and on parasite-derived microvesicles that transfer between cells and stimulate gametocyte production. In Chapter 4, I and coauthors present a protocol for measuring parasite growth and gametocyte production in response to drugs or other treatments.
590 $a School code: 0084.
650 4 $a Parasitology. $3 635062
650 4 $a Microbiology. $3 536250
650 4 $a Molecular biology. $3 517296
690 $a 0718
690 $a 0410
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710 2 $a Harvard University. $b Chemical Biology. $3 3172793
773 0 $t Dissertation Abstracts International $g 77-04B(E).
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791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3738787