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Synthesis of polymeric materials for...

Kramer, Stephanie A.

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Synthesis of polymeric materials for drug delivery and industrial applications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis of polymeric materials for drug delivery and industrial applications./
Author:	Kramer, Stephanie A.
Description:	116 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
Contained By:	Dissertation Abstracts International76-09B(E).
Subject:	Inorganic chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3703834
ISBN:	9781321758870

Synthesis of polymeric materials for drug delivery and industrial applications.
Kramer, Stephanie A.

Synthesis of polymeric materials for drug delivery and industrial applications. - 116 p.

Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2015.

This item is not available from ProQuest Dissertations & Theses.

This dissertation reports the synthesis of polymeric materials for industrial and medicinal applications. Depending on their chemical structure, polymers have different properties and applications. Polyolefins, used in packaging and films, are one of the most highly produced polymeric materials in industry, whereas only a handful of polymeric materials are in the market for drug delivery.

ISBN: 9781321758870Subjects--Topical Terms:

3173556
Inorganic chemistry.

Synthesis of polymeric materials for drug delivery and industrial applications.
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100 1 $a Kramer, Stephanie A. $3 3192967
245 1 0 $a Synthesis of polymeric materials for drug delivery and industrial applications.
300 $a 116 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
500 $a Adviser: Michel R. Gagne.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2015.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a This dissertation reports the synthesis of polymeric materials for industrial and medicinal applications. Depending on their chemical structure, polymers have different properties and applications. Polyolefins, used in packaging and films, are one of the most highly produced polymeric materials in industry, whereas only a handful of polymeric materials are in the market for drug delivery.
520 $a The first part of this thesis presents a method to deoxygenate linear polyols producing branched polyolefins. In Chapter 2, linear polyols, such as poly(vinyl alcohol) (PVA), are hydrosilylatively deoxygenated using catalytic amounts of B(C6F5)3 and a reducing hydrosilane. Following reduction, a highly branched, predominantly saturated structure is obtained. Depending on the alcohol-protecting group and the hydrosilane used, the branch numbers can exceed 200 branches per 1000 carbons. The branching microstructure is also dependent on the protecting group and silane. For instance, the deoxygenation of TMS-protected PVA with diethylsilane produced a polymer with different branch types when compared to the polymer that results from the deoxygenation of TES-protected PVA.
520 $a The B(C6F5)3-catalyzed deoxygenation was applied to a triblock system wherein the central block was a 1,5-polyol structure to produce otherwise inaccessible triblock polymers with an amorphously branched interior block (Chapter 3). The starting polymer was obtained by sequential hydroboration/oxidation of poly(styrene-b-butadiene- b-styrene) (SBS), which converts the polybutadiene block into a 1,5-polyol block. The hydroxylated SBS polymer was then completely deoxygenated to yield a novel triblock polymer with a highly branched interior, with the branching being predominantly butyl or longer chains as established by 13C-NMR spectroscopy. The structure-property relationships of this new triblock system still need to be investigated and compared to SBS. The second section of this thesis discusses an alternative drug delivery approach utilizing nanoscale coordination polymers (NCPs). Chapter 4 presents the synthesis of Ca(II) and Mn(II)-based NCP formulations containing a cisplatin prodrug. Coating the NCPs with a lipid bilayer stabilized both of these formulations. Drug release profiles demonstrated sustained cisplatin release from the NCPs. Drug loadings of 20% for Ca-based NCP and 25% for Mn-NCP were determined. Due to the exceptionally high drug loadings and nanoscale size, these cisplatin NCPs are promising drug delivery candidates.
590 $a School code: 0153.
650 4 $a Inorganic chemistry. $3 3173556
650 4 $a Analytical chemistry. $3 3168300
650 4 $a Organic chemistry. $3 523952
690 $a 0488
690 $a 0486
690 $a 0490
710 2 $a The University of North Carolina at Chapel Hill. $b Chemistry. $3 1021872
773 0 $t Dissertation Abstracts International $g 76-09B(E).
790 $a 0153
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3703834