東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Theoretical and Experimental Investi...

Richardson, Mandek.

Linked to FindBook

Google Book

Amazon

博客來

Theoretical and Experimental Investigations to Improve the Performance of Surface Acoustic Wave (SAW) Biosensors.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Theoretical and Experimental Investigations to Improve the Performance of Surface Acoustic Wave (SAW) Biosensors./
Author:	Richardson, Mandek.
Description:	157 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
Contained By:	Dissertation Abstracts International76-09B(E).
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3689315
ISBN:	9781321684971

Theoretical and Experimental Investigations to Improve the Performance of Surface Acoustic Wave (SAW) Biosensors.
Richardson, Mandek.

Theoretical and Experimental Investigations to Improve the Performance of Surface Acoustic Wave (SAW) Biosensors. - 157 p.

Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.

Thesis (Ph.D.)--University of South Florida, 2015.

The objective of this dissertation is to improve the performance of surface acoustic wave (SAW) biosensors for use in point-of-care-testing (POCT) applications. SAW biosensors have the ability to perform fast, accurate detection of an analyte in real time without the use of labels. However, the technology suffers from the inability to differentiate between specific and non-specific binding. Due to this limitation, direct testing of bodily fluids using SAW sensors to accurately determine an analyte's concentration is difficult. In addition, these sensors are challenged by the need to detect small concentrations of a biomarker that are typically required to give a clinical diagnosis. Sensitivity, selectivity and reliability are three critical aspects for any sensing platform. To improve sensitivity the delay path of a SAW sensor has been modified with microcavities filled with various materials. These filled cavities increased sensitivity by confining wave energy to the surface by way of constructive interference and waveguiding. Thus, the improved sensitivity will result in a lower limit of detection. In addition, insertion loss is decreased as a consequence of increased wave confinement to the surface. Sensor selectivity and reliability are adversely affected by non-specific binding of unwanted species present in a sample. To address this issue a multifunctional SAW sensor is presented. The sensor consists of two SAW delay lines oriented orthogonal to each on ST-quartz in order to generate two distinct wave modes. One wave mode is used for sensing while the other is used to remove loosely bound material. By using the same transduction mechanism for both removal and sensing, the sensor chip is simplified and complex electronics are avoided. The findings of this research involve the technological advances for SAW biosensors that make their use in POCT possible.

ISBN: 9781321684971Subjects--Topical Terms:

535387
Biomedical engineering.

Theoretical and Experimental Investigations to Improve the Performance of Surface Acoustic Wave (SAW) Biosensors.
LDR:02841nmm a2200289 4500 001 2077422
005 20161114130311.5
008 170521s2015 ||||||||||||||||| ||eng d
020 $a 9781321684971
035 $a (MiAaPQ)AAI3689315
035 $a AAI3689315
040 $a MiAaPQ $c MiAaPQ
100 1 $a Richardson, Mandek. $3 3192926
245 1 0 $a Theoretical and Experimental Investigations to Improve the Performance of Surface Acoustic Wave (SAW) Biosensors.
300 $a 157 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
500 $a Adviser: Venkat R. Bhethanabotla.
502 $a Thesis (Ph.D.)--University of South Florida, 2015.
520 $a The objective of this dissertation is to improve the performance of surface acoustic wave (SAW) biosensors for use in point-of-care-testing (POCT) applications. SAW biosensors have the ability to perform fast, accurate detection of an analyte in real time without the use of labels. However, the technology suffers from the inability to differentiate between specific and non-specific binding. Due to this limitation, direct testing of bodily fluids using SAW sensors to accurately determine an analyte's concentration is difficult. In addition, these sensors are challenged by the need to detect small concentrations of a biomarker that are typically required to give a clinical diagnosis. Sensitivity, selectivity and reliability are three critical aspects for any sensing platform. To improve sensitivity the delay path of a SAW sensor has been modified with microcavities filled with various materials. These filled cavities increased sensitivity by confining wave energy to the surface by way of constructive interference and waveguiding. Thus, the improved sensitivity will result in a lower limit of detection. In addition, insertion loss is decreased as a consequence of increased wave confinement to the surface. Sensor selectivity and reliability are adversely affected by non-specific binding of unwanted species present in a sample. To address this issue a multifunctional SAW sensor is presented. The sensor consists of two SAW delay lines oriented orthogonal to each on ST-quartz in order to generate two distinct wave modes. One wave mode is used for sensing while the other is used to remove loosely bound material. By using the same transduction mechanism for both removal and sensing, the sensor chip is simplified and complex electronics are avoided. The findings of this research involve the technological advances for SAW biosensors that make their use in POCT possible.
590 $a School code: 0206.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Acoustics. $3 879105
650 4 $a Biogeochemistry. $3 545717
690 $a 0541
690 $a 0986
690 $a 0425
710 2 $a University of South Florida. $b Chemical Engineering. $3 1685195
773 0 $t Dissertation Abstracts International $g 76-09B(E).
790 $a 0206
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3689315