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Characterizing the Binding Potential...

Fang, Mingliang.

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Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARgamma) Ligands in Indoor Dust.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARgamma) Ligands in Indoor Dust./
Author:	Fang, Mingliang.
Description:	226 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-08(E), Section: B.
Contained By:	Dissertation Abstracts International76-08B(E).
Subject:	Environmental health. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3686150
ISBN:	9781321628883

Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARgamma) Ligands in Indoor Dust.
Fang, Mingliang.

Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARgamma) Ligands in Indoor Dust. - 226 p.

Source: Dissertation Abstracts International, Volume: 76-08(E), Section: B.

Thesis (Ph.D.)--Duke University, 2015.

This item is not available from ProQuest Dissertations & Theses.

Accumulating evidence is suggesting that exposure to some environmental contaminants may alter adipogenesis, resulting in accumulation of adipocytes, and often significant weight gain. Thus these types of contaminants are often referred to as obesogens. Many of these contaminants act via the activation (i.e. agonism) of the peroxisome proliferator activated receptor gamma (PPARgamma) nuclear receptor. To date, very few chemicals have been identified as possible PPARgamma ligands. In the thesis, our goal was to determine the PPARgamma ligand binding potency and activation of several groups of major semi-volatile organic compounds (SVOCs) that are ubiquitously detected in indoor environments, including flame retardants such as polybrominated diphenyl ethers (PBDEs) and Firemaster 550 (FM550), and other SVOCs such as phthalates, organotins, halogenated phenols and bisphenols. Additional attention was also given to the potential activity of the major metabolites of several of these compounds. Since the primary sink for many of these SVOCs is dust, and dust ingestion has been confirmed as an important pathway for SVOCs accumulation in humans, the potential PPARgamma binding and activation in extracts from environmentally relevant dust samples was also investigated. (Abstract shortened by UMI.).

ISBN: 9781321628883Subjects--Topical Terms:

543032
Environmental health.

Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARgamma) Ligands in Indoor Dust.
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245 1 0 $a Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARgamma) Ligands in Indoor Dust.
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500 $a Adviser: Heather M. Stapleton.
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506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Accumulating evidence is suggesting that exposure to some environmental contaminants may alter adipogenesis, resulting in accumulation of adipocytes, and often significant weight gain. Thus these types of contaminants are often referred to as obesogens. Many of these contaminants act via the activation (i.e. agonism) of the peroxisome proliferator activated receptor gamma (PPARgamma) nuclear receptor. To date, very few chemicals have been identified as possible PPARgamma ligands. In the thesis, our goal was to determine the PPARgamma ligand binding potency and activation of several groups of major semi-volatile organic compounds (SVOCs) that are ubiquitously detected in indoor environments, including flame retardants such as polybrominated diphenyl ethers (PBDEs) and Firemaster 550 (FM550), and other SVOCs such as phthalates, organotins, halogenated phenols and bisphenols. Additional attention was also given to the potential activity of the major metabolites of several of these compounds. Since the primary sink for many of these SVOCs is dust, and dust ingestion has been confirmed as an important pathway for SVOCs accumulation in humans, the potential PPARgamma binding and activation in extracts from environmentally relevant dust samples was also investigated. (Abstract shortened by UMI.).
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