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Sphingolipids and the Control of Fat...

Olson, Daniel K.

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Sphingolipids and the Control of Fatty Acid Synthesis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Sphingolipids and the Control of Fatty Acid Synthesis./
Author:	Olson, Daniel K.
Description:	72 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-06(E), Section: B.
Contained By:	Dissertation Abstracts International77-06B(E).
Subject:	Cellular biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10013003
ISBN:	9781339478296

Sphingolipids and the Control of Fatty Acid Synthesis.
Olson, Daniel K.

Sphingolipids and the Control of Fatty Acid Synthesis. - 72 p.

Source: Dissertation Abstracts International, Volume: 77-06(E), Section: B.

Thesis (Ph.D.)--Yale University, 2015.

Sphingolipids (SL) are essential components of eukaryotic cells involved maintaining membrane integrity. They are important for membrane trafficking and function in signaling as messenger molecules. SLs are synthesized de novo from very long chain fatty acids (VLCFA) and sphingoid long-chain bases (LCB), which are amide-linked to form ceramide and further processed by addition of various head-groups. Little is known concerning the regulation of VLCFA levels and how cells coordinate their synthesis with the availability of LCBs for SL synthesis. Here I show that Elo2, a key enzyme of VLCFA synthesis, is controlled by signaling of the guanine nucleotide exchange factor Rom2, initiating at the plasma membrane. This pathway controls Elo2 phosphorylation state and VLCFA synthesis. My data identify a regulatory mechanism for coordinating VLCFA synthesis with SL metabolism and link signal transduction pathways from the plasma membrane to the regulation of lipids for membrane homeostasj.

ISBN: 9781339478296Subjects--Topical Terms:

3172791
Cellular biology.

Sphingolipids and the Control of Fatty Acid Synthesis.
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020 $a 9781339478296
035 $a (MiAaPQ)AAI10013003
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100 1 $a Olson, Daniel K. $3 3192604
245 1 0 $a Sphingolipids and the Control of Fatty Acid Synthesis.
300 $a 72 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-06(E), Section: B.
500 $a Adviser: Tobias Walther.
502 $a Thesis (Ph.D.)--Yale University, 2015.
520 $a Sphingolipids (SL) are essential components of eukaryotic cells involved maintaining membrane integrity. They are important for membrane trafficking and function in signaling as messenger molecules. SLs are synthesized de novo from very long chain fatty acids (VLCFA) and sphingoid long-chain bases (LCB), which are amide-linked to form ceramide and further processed by addition of various head-groups. Little is known concerning the regulation of VLCFA levels and how cells coordinate their synthesis with the availability of LCBs for SL synthesis. Here I show that Elo2, a key enzyme of VLCFA synthesis, is controlled by signaling of the guanine nucleotide exchange factor Rom2, initiating at the plasma membrane. This pathway controls Elo2 phosphorylation state and VLCFA synthesis. My data identify a regulatory mechanism for coordinating VLCFA synthesis with SL metabolism and link signal transduction pathways from the plasma membrane to the regulation of lipids for membrane homeostasj.
590 $a School code: 0265.
650 4 $a Cellular biology. $3 3172791
650 4 $a Biochemistry. $3 518028
650 4 $a Biology. $3 522710
690 $a 0379
690 $a 0487
690 $a 0306
710 2 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 77-06B(E).
790 $a 0265
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10013003