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Neural, cognitive, and clinical corr...

Kent, Jerillyn Suzanne.

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Neural, cognitive, and clinical correlates of cerebellar-dependent associative learning in individuals with schizophrenia.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Neural, cognitive, and clinical correlates of cerebellar-dependent associative learning in individuals with schizophrenia./
Author:	Kent, Jerillyn Suzanne.
Description:	154 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.
Contained By:	Dissertation Abstracts International77-02B(E).
Subject:	Psychobiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3722967
ISBN:	9781339054285

Neural, cognitive, and clinical correlates of cerebellar-dependent associative learning in individuals with schizophrenia.
Kent, Jerillyn Suzanne.

Neural, cognitive, and clinical correlates of cerebellar-dependent associative learning in individuals with schizophrenia. - 154 p.

Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.

Thesis (Ph.D.)--Indiana University, 2015.

Cerebellar abnormalities in schizophrenia are hypothesized to contribute to disturbances in the fluidity and coordination of motor, cognitive, and affective processes. Most evidence of cerebellar dysfunction in schizophrenia is behavioral, or consists of structural or incidental fMRI findings. We examined cerebellar neural function using fMRI during a cerebellar-dependent task in schizophrenia. Ten individuals with schizophrenia and 20 non-psychiatric controls underwent three 11.5 minute runs of simultaneous fMRI and delay eyeblink conditioning (EBC). Twenty-six airpuffs and 26 tones were presented during run one (pseudoconditioning). Fifty-two paired trials (tone and airpuff) were presented during runs two (acquisition) and three (maintenance). Behavioral results revealed a significant block x group interaction (p = 0.037), with controls producing higher rates of conditioning over the course of the experiment. Imaging results for the acquisition run revealed significant activation in left Crus I in controls but no significant activation in individuals with schizophrenia (p < 0.001, extent threshold = 18 voxels) when groups were analyzed separately. Group comparisons revealed significantly increased activation in the right dentate nucleus in controls. Controls also demonstrated significant activation in left Crus I, bilateral lobule VIIIa, and vermis lobule VI during the maintenance run. Activation in vermis lobule VIIIa and right Crus II was positively correlated with IQ scores in individuals with schizophrenia but not controls. Negative symptom severity was negatively correlated with cerebellar activation in individuals with schizophrenia in right Crus I, right Crus II, and right dentate nucleus. Results suggest that cerebellar neural activity is diminished in individuals with schizophrenia while the cerebellum is being directly recruited by EBC, and that EBC impairments in individuals with schizophrenia may be driven by abnormal neural activity in the cerebellum during learning. Cognitive and clinical correlates of cerebellar activation suggest that cerebellar function may be related to the cardinal cognitive and affective symptoms of schizophrenia.

ISBN: 9781339054285Subjects--Topical Terms:

555678
Psychobiology.

Neural, cognitive, and clinical correlates of cerebellar-dependent associative learning in individuals with schizophrenia.
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245 1 0 $a Neural, cognitive, and clinical correlates of cerebellar-dependent associative learning in individuals with schizophrenia.
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500 $a Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.
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520 $a Cerebellar abnormalities in schizophrenia are hypothesized to contribute to disturbances in the fluidity and coordination of motor, cognitive, and affective processes. Most evidence of cerebellar dysfunction in schizophrenia is behavioral, or consists of structural or incidental fMRI findings. We examined cerebellar neural function using fMRI during a cerebellar-dependent task in schizophrenia. Ten individuals with schizophrenia and 20 non-psychiatric controls underwent three 11.5 minute runs of simultaneous fMRI and delay eyeblink conditioning (EBC). Twenty-six airpuffs and 26 tones were presented during run one (pseudoconditioning). Fifty-two paired trials (tone and airpuff) were presented during runs two (acquisition) and three (maintenance). Behavioral results revealed a significant block x group interaction (p = 0.037), with controls producing higher rates of conditioning over the course of the experiment. Imaging results for the acquisition run revealed significant activation in left Crus I in controls but no significant activation in individuals with schizophrenia (p < 0.001, extent threshold = 18 voxels) when groups were analyzed separately. Group comparisons revealed significantly increased activation in the right dentate nucleus in controls. Controls also demonstrated significant activation in left Crus I, bilateral lobule VIIIa, and vermis lobule VI during the maintenance run. Activation in vermis lobule VIIIa and right Crus II was positively correlated with IQ scores in individuals with schizophrenia but not controls. Negative symptom severity was negatively correlated with cerebellar activation in individuals with schizophrenia in right Crus I, right Crus II, and right dentate nucleus. Results suggest that cerebellar neural activity is diminished in individuals with schizophrenia while the cerebellum is being directly recruited by EBC, and that EBC impairments in individuals with schizophrenia may be driven by abnormal neural activity in the cerebellum during learning. Cognitive and clinical correlates of cerebellar activation suggest that cerebellar function may be related to the cardinal cognitive and affective symptoms of schizophrenia.
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