東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

A Neurogenetic and Genomic Character...

James, Alexander Scott.

Linked to FindBook

Google Book

Amazon

博客來

A Neurogenetic and Genomic Characterization of Reward-Seeking Behaviors.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A Neurogenetic and Genomic Characterization of Reward-Seeking Behaviors./
Author:	James, Alexander Scott.
Description:	161 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-11(E), Section: B.
Contained By:	Dissertation Abstracts International75-11B(E).
Subject:	Nanoscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3628738
ISBN:	9781321050455

A Neurogenetic and Genomic Characterization of Reward-Seeking Behaviors.
James, Alexander Scott.

A Neurogenetic and Genomic Characterization of Reward-Seeking Behaviors. - 161 p.

Source: Dissertation Abstracts International, Volume: 75-11(E), Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2014.

This item is not available from ProQuest Dissertations & Theses.

Because Pavlovian and instrumental processes enabling the prediction and pursuit of desired rewards, as well as the avoidance of dangers and noxious stimuli, they are integral to a wide range of behaviors that we exhibit. The studies presented here combine hypothesis-based studies with hypothesis-free research in order to provide novel insight into the reward-seeking behaviors that shape human behavior, and importantly, when expressed in extreme forms, are components of and risk factors for a range of psychiatric conditions. The first series of studies in this dissertation sought to disentangle the complex role of NMDA-mediated dopamine cell burst firing in reward-related learning, and to test causally, for the first time, predictions made by the incentive salience account of phasic dopamine function. While instrumental learning was impaired in our genetic model of attenuated phasic dopamine release, we found no evidence to support a selective dependency of incentive salience attribution on phasic dopamine release. Rather, our data are congruent with an integrative perspective on the role of phasic dopamine release in reward-driven learning, rather unitary theories of dopamine as a prediction error or incentive salience signal. The second study sought new genomic determinants of variation in reward seeking, using association-level genome-wide scans in an inbred mouse strain panel combined with linear mixed effects modeling, and yielded several quantitative trait loci related to quantitative variation in instrumental responding for sucrose. Transcriptomics data was used to for prioritizing quantitative trait loci genes for future causal studies, and offered a resource for the development of new hypotheses regarding the neurobiology that links genes to behavior in the context of reward-related learning. Moreover, the specific pattern of transcriptomics and genomics data acquired was suggestive of a common underlying genomic and transcriptomics basis for motivational and learning processes in instrumental behavior. The data collected in this dissertation offer new neurobiological understanding of behaviors that are germane to psychiatric conditions, and demonstrate the synergy offered by combining both hypothesis-based and hypothesis-free approaches to behavioral neuroscience research.

ISBN: 9781321050455Subjects--Topical Terms:

587832
Nanoscience.

A Neurogenetic and Genomic Characterization of Reward-Seeking Behaviors.
LDR:03327nmm a2200313 4500 001 2076294
005 20161028121101.5
008 170521s2014 ||||||||||||||||| ||eng d
020 $a 9781321050455
035 $a (MiAaPQ)AAI3628738
035 $a AAI3628738
040 $a MiAaPQ $c MiAaPQ
100 1 $a James, Alexander Scott. $3 3191738
245 1 2 $a A Neurogenetic and Genomic Characterization of Reward-Seeking Behaviors.
300 $a 161 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-11(E), Section: B.
500 $a Adviser: David Jentsch.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2014.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Because Pavlovian and instrumental processes enabling the prediction and pursuit of desired rewards, as well as the avoidance of dangers and noxious stimuli, they are integral to a wide range of behaviors that we exhibit. The studies presented here combine hypothesis-based studies with hypothesis-free research in order to provide novel insight into the reward-seeking behaviors that shape human behavior, and importantly, when expressed in extreme forms, are components of and risk factors for a range of psychiatric conditions. The first series of studies in this dissertation sought to disentangle the complex role of NMDA-mediated dopamine cell burst firing in reward-related learning, and to test causally, for the first time, predictions made by the incentive salience account of phasic dopamine function. While instrumental learning was impaired in our genetic model of attenuated phasic dopamine release, we found no evidence to support a selective dependency of incentive salience attribution on phasic dopamine release. Rather, our data are congruent with an integrative perspective on the role of phasic dopamine release in reward-driven learning, rather unitary theories of dopamine as a prediction error or incentive salience signal. The second study sought new genomic determinants of variation in reward seeking, using association-level genome-wide scans in an inbred mouse strain panel combined with linear mixed effects modeling, and yielded several quantitative trait loci related to quantitative variation in instrumental responding for sucrose. Transcriptomics data was used to for prioritizing quantitative trait loci genes for future causal studies, and offered a resource for the development of new hypotheses regarding the neurobiology that links genes to behavior in the context of reward-related learning. Moreover, the specific pattern of transcriptomics and genomics data acquired was suggestive of a common underlying genomic and transcriptomics basis for motivational and learning processes in instrumental behavior. The data collected in this dissertation offer new neurobiological understanding of behaviors that are germane to psychiatric conditions, and demonstrate the synergy offered by combining both hypothesis-based and hypothesis-free approaches to behavioral neuroscience research.
590 $a School code: 0031.
650 4 $a Nanoscience. $3 587832
650 4 $a Behavioral psychology. $3 2122788
650 4 $a Genetics. $3 530508
650 4 $a Neurosciences. $3 588700
690 $a 0565
690 $a 0384
690 $a 0369
690 $a 0317
710 2 $a University of California, Los Angeles. $b Psychology. $3 2103527
773 0 $t Dissertation Abstracts International $g 75-11B(E).
790 $a 0031
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3628738