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Development of filter device to limi...

Yu, Jay.

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Development of filter device to limit systemic toxicity from doxorubicin chemotherapy: DNA ChemoFilter.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development of filter device to limit systemic toxicity from doxorubicin chemotherapy: DNA ChemoFilter./
Author:	Yu, Jay.
Description:	25 p.
Notes:	Source: Masters Abstracts International, Volume: 55-01.
Contained By:	Masters Abstracts International55-01(E).
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1600669
ISBN:	9781339099187

Development of filter device to limit systemic toxicity from doxorubicin chemotherapy: DNA ChemoFilter.
Yu, Jay.

Development of filter device to limit systemic toxicity from doxorubicin chemotherapy: DNA ChemoFilter. - 25 p.

Source: Masters Abstracts International, Volume: 55-01.

Thesis (M.S.)--University of California, San Francisco, 2015.

Objective: ChemoFilter is a new class of image-guided temporarily deployable, endovascular catheter based medical device that selectively filters chemotherapeutic agents from the bloodstream to limit systemic toxicities. We report a novel method to filter doxorubicin in blood using genomic DNA as resin.

ISBN: 9781339099187Subjects--Topical Terms:

535387
Biomedical engineering.

Development of filter device to limit systemic toxicity from doxorubicin chemotherapy: DNA ChemoFilter.
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020 $a 9781339099187
035 $a (MiAaPQ)AAI1600669
035 $a AAI1600669
040 $a MiAaPQ $c MiAaPQ
100 1 $a Yu, Jay. $3 3191325
245 1 0 $a Development of filter device to limit systemic toxicity from doxorubicin chemotherapy: DNA ChemoFilter.
300 $a 25 p.
500 $a Source: Masters Abstracts International, Volume: 55-01.
500 $a Adviser: Steven Hetts.
502 $a Thesis (M.S.)--University of California, San Francisco, 2015.
520 $a Objective: ChemoFilter is a new class of image-guided temporarily deployable, endovascular catheter based medical device that selectively filters chemotherapeutic agents from the bloodstream to limit systemic toxicities. We report a novel method to filter doxorubicin in blood using genomic DNA as resin.
520 $a Materials and Methods: DNA binding experiments were performed in vitro with doxorubicin in PBS solution and porcine serum. Genomic DNA was used for binding experiments, with the DNA either free in solutions or with the DNA encapsulated in packets made with nylon or polyester mesh. Optimum concentration of genomic DNA to filter 50 mg doxorubicin in solution was determined. We then compared the kinetics of filtering doxorubicin by genomic DNA as compared to our previously published ion exchange resin based ChemoFilter.
520 $a Results: Doxorubicin concentration was reduced by over 90% within 1 minute with free DNA in PBS and porcine serum. With packaged DNA, doxorubicin concentration was reduced by 50% within 5 minutes in PBS, and 90% within 1 minute in porcine Serum. Doxorubicin filtering kinetics between DNA and the ion exchange resin Dowex were compared in each binding experiments and the DNA displayed more rapid kinetics in all situations.
520 $a Conclusion: We describe a new version of ChemoFilter that uses DNA as the binding agent for DNA binding drugs. DNA ChemoFilter allows selective filtration of DNA binding chemotherapeutic agents and demonstrates more rapid kinetics than previously described ion exchange version of ChemoFilter.
590 $a School code: 0034.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Medical imaging. $3 3172799
650 4 $a Medicine. $3 641104
690 $a 0541
690 $a 0574
690 $a 0564
710 2 $a University of California, San Francisco. $b Biomedical Imaging. $3 2106351
773 0 $t Masters Abstracts International $g 55-01(E).
790 $a 0034
791 $a M.S.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1600669