東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

The effect of curcumin on cardiovasc...

Campbell, Marilyn Suzanne.

Linked to FindBook

Google Book

Amazon

博客來

The effect of curcumin on cardiovascular health in obese men.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The effect of curcumin on cardiovascular health in obese men./
Author:	Campbell, Marilyn Suzanne.
Description:	174 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
Contained By:	Dissertation Abstracts International77-10B(E).
Subject:	Kinesiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10109780
ISBN:	9781339730493

The effect of curcumin on cardiovascular health in obese men.
Campbell, Marilyn Suzanne.

The effect of curcumin on cardiovascular health in obese men. - 174 p.

Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.

Thesis (Ph.D.)--University of Kentucky, 2016.

Cardiovascular disease is the leading cause of death in the United States, and conventional treatment often emphasizes pharmaceutical approaches. Research has recently started exploring non-pharmaceutical approaches, including nutritional interventions. This research study was conducted to test the effectiveness of a novel nutritional approach, curcumin, on the improvement of cardiovascular health in young, obese males (BMI=30 kg/m2). This study included 22 men, matched based on BMI and randomly assigned to the intervention (n=11) or placebo group (n=11). The intervention consisted of 12 weeks of curcumin supplementation (1.0 g/day) with fenugreek added to enhance the curcumin bioavailability; the placebo consisted of 12 weeks of equal parts fenugreek to that found in the intervention. To determine cardiovascular improvements, arterial stiffness via gold-standard carotid-femoral pulse wave velocity (cfPWV), endothelial dysfunction via reactive hyperemia index (RHI), and inflammation via plasma cytokine concentrations were measured. There were no overall differences in cfPWV (p=0.428) or RHI (p=0.951) between groups following the 12 weeks of intervention. However, some individuals did respond to the curcumin treatment with reductions in cfPWV, while others did not. Subjects who did respond to the curcumin treatment (n=6) entered the study with higher baseline values of cfPWV than those that did not respond (n=5) (6.81 m/s v. 5.84 m/s, p = 0.045). This suggests a potential role for curcumin to improve arterial stiffness in individuals with stiffer arteries at baseline. A possible mechanism to explain the difference in responsiveness is a trending increase in IL-13 (p=0.052), an anti-inflammatory cytokine that has been associated with amelioration of collagen content in the arteries. Also, 12 weeks of curcumin intervention resulted in reductions in brachial pulse pressure (p<0.05), a surrogate marker of arterial stiffness. This change in brachial pulse pressure in the curcumin group could be explained by an increased trend in anti-inflammatory cytokine IL-10 (p=0.071), but further studies are required to confirm this finding. Based on the findings of this study, curcumin might serve as a non-pharmaceutical intervention to improve vascular health in young obese men, especially when arteries are stiffer than age-matched counterparts.

ISBN: 9781339730493Subjects--Topical Terms:

517627
Kinesiology.

The effect of curcumin on cardiovascular health in obese men.
LDR:03405nmm a2200301 4500 001 2074317
005 20160926125811.5
008 170521s2016 ||||||||||||||||| ||eng d
020 $a 9781339730493
035 $a (MiAaPQ)AAI10109780
035 $a AAI10109780
040 $a MiAaPQ $c MiAaPQ
100 1 $a Campbell, Marilyn Suzanne. $3 3189617
245 1 4 $a The effect of curcumin on cardiovascular health in obese men.
300 $a 174 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
500 $a Advisers: Bradley Fleenor; Jody Clasey.
502 $a Thesis (Ph.D.)--University of Kentucky, 2016.
520 $a Cardiovascular disease is the leading cause of death in the United States, and conventional treatment often emphasizes pharmaceutical approaches. Research has recently started exploring non-pharmaceutical approaches, including nutritional interventions. This research study was conducted to test the effectiveness of a novel nutritional approach, curcumin, on the improvement of cardiovascular health in young, obese males (BMI=30 kg/m2). This study included 22 men, matched based on BMI and randomly assigned to the intervention (n=11) or placebo group (n=11). The intervention consisted of 12 weeks of curcumin supplementation (1.0 g/day) with fenugreek added to enhance the curcumin bioavailability; the placebo consisted of 12 weeks of equal parts fenugreek to that found in the intervention. To determine cardiovascular improvements, arterial stiffness via gold-standard carotid-femoral pulse wave velocity (cfPWV), endothelial dysfunction via reactive hyperemia index (RHI), and inflammation via plasma cytokine concentrations were measured. There were no overall differences in cfPWV (p=0.428) or RHI (p=0.951) between groups following the 12 weeks of intervention. However, some individuals did respond to the curcumin treatment with reductions in cfPWV, while others did not. Subjects who did respond to the curcumin treatment (n=6) entered the study with higher baseline values of cfPWV than those that did not respond (n=5) (6.81 m/s v. 5.84 m/s, p = 0.045). This suggests a potential role for curcumin to improve arterial stiffness in individuals with stiffer arteries at baseline. A possible mechanism to explain the difference in responsiveness is a trending increase in IL-13 (p=0.052), an anti-inflammatory cytokine that has been associated with amelioration of collagen content in the arteries. Also, 12 weeks of curcumin intervention resulted in reductions in brachial pulse pressure (p<0.05), a surrogate marker of arterial stiffness. This change in brachial pulse pressure in the curcumin group could be explained by an increased trend in anti-inflammatory cytokine IL-10 (p=0.071), but further studies are required to confirm this finding. Based on the findings of this study, curcumin might serve as a non-pharmaceutical intervention to improve vascular health in young obese men, especially when arteries are stiffer than age-matched counterparts.
520 $a Keywords: Turmeric, Arterial stiffness, Carotid-femoral pulse wave velocity (cfPWV), Cardiovascular disease (CVD), Obesity.
590 $a School code: 0102.
650 4 $a Kinesiology. $3 517627
650 4 $a Nutrition. $3 517777
650 4 $a Pharmacology. $3 634543
690 $a 0575
690 $a 0570
690 $a 0419
710 2 $a University of Kentucky. $b Kinesiology and Health Promotion. $3 3189618
773 0 $t Dissertation Abstracts International $g 77-10B(E).
790 $a 0102
791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10109780