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The role of TREM2 in the regulation ...

Bemiller, Shane M.

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The role of TREM2 in the regulation of Alzheimer's Disease.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The role of TREM2 in the regulation of Alzheimer's Disease./
Author:	Bemiller, Shane M.
Description:	163 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
Contained By:	Dissertation Abstracts International77-10B(E).
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10109137
ISBN:	9781339724386

The role of TREM2 in the regulation of Alzheimer's Disease.
Bemiller, Shane M.

The role of TREM2 in the regulation of Alzheimer's Disease. - 163 p.

Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.

Thesis (Ph.D.)--Kent State University, 2016.

Alzheimer's Disease (AD) is a leading cause of death and disability in elderly populations. There is currently no way to treat AD, and diagnosis can still only be definitively achieved post-mortem. Recently identified coding alterations in Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) have been identified which substantially increase risk of developing late-onset AD (LOAD). In the current thesis, we examine the role of TREM2 in regulating AD related tau pathology and determine that TREM2 plays overall protective roles in regulating intraneuronal MAPT pathology. In addition, we characterize TREM2 expression in human peripheral blood monocytes, and determine that AD patients exhibit increased levels of inflammatory TREM2 positive monocytes. Our studies identify a novel target which may be utilized for the development of future AD therapeutics.

ISBN: 9781339724386Subjects--Topical Terms:

588700
Neurosciences.

The role of TREM2 in the regulation of Alzheimer's Disease.
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245 1 4 $a The role of TREM2 in the regulation of Alzheimer's Disease.
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500 $a Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
500 $a Adviser: Bruce T. Lamb.
502 $a Thesis (Ph.D.)--Kent State University, 2016.
520 $a Alzheimer's Disease (AD) is a leading cause of death and disability in elderly populations. There is currently no way to treat AD, and diagnosis can still only be definitively achieved post-mortem. Recently identified coding alterations in Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) have been identified which substantially increase risk of developing late-onset AD (LOAD). In the current thesis, we examine the role of TREM2 in regulating AD related tau pathology and determine that TREM2 plays overall protective roles in regulating intraneuronal MAPT pathology. In addition, we characterize TREM2 expression in human peripheral blood monocytes, and determine that AD patients exhibit increased levels of inflammatory TREM2 positive monocytes. Our studies identify a novel target which may be utilized for the development of future AD therapeutics.
590 $a School code: 0101.
650 4 $a Neurosciences. $3 588700
650 4 $a Pathology. $3 643180
690 $a 0317
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710 2 $a Kent State University. $b College of Arts and Sciences / Department of Biological Sciences. $3 3189612
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793 $a English
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