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Comparison of Hemodynamic Responses ...

Zeigler, Zachary S.

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Comparison of Hemodynamic Responses to Acute and Chronic Exercise in Obese and Lean Prehypertensive Men.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Comparison of Hemodynamic Responses to Acute and Chronic Exercise in Obese and Lean Prehypertensive Men./
作者:	Zeigler, Zachary S.
面頁冊數:	104 p.
附註:	Source: Dissertation Abstracts International, Volume: 77-09(E), Section: B.
Contained By:	Dissertation Abstracts International77-09B(E).
標題:	Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10108060
ISBN:	9781339714356

Comparison of Hemodynamic Responses to Acute and Chronic Exercise in Obese and Lean Prehypertensive Men.
Zeigler, Zachary S.

Comparison of Hemodynamic Responses to Acute and Chronic Exercise in Obese and Lean Prehypertensive Men. - 104 p.

Source: Dissertation Abstracts International, Volume: 77-09(E), Section: B.

Thesis (Ph.D.)--Arizona State University, 2016.

PURPOSE: Lean hypertension (HTN) is characterized by a mechanistically different HTN when compared to obese HTN. The purpose of this study is to assess whether body phenotype influences blood pressure (BP) responses following both acute and chronic exercise. METHODS: Obese (body mass index (BMI) > 30 kg/m2) and lean (BMI < 25 kg/m2) men with pre-hypertension (PHTN) (systolic BP (SBP) 120--139 or diastolic BP (DBP) 80--89 mm Hg) were asked to participate in a two-phase trial. Phase 1 assessed differences in post-exercise hypotension between groups in response to an acute exercise bout. Phase 2 consisted of a two-week aerobic exercise intervention at 65--70% of heart rate (HR) max on a cycle ergometer. Primary outcome measures were: brachial BP, central (aortic) BP, cardiac output (CO), and systemic vascular resistance (SVR) measured acutely after one exercise session and following two weeks of training. RESULTS: There were no differences between groups for baseline resting brachial BP, central BP, age, or VO 2 peak (all P > 0.05). At rest, obese PHTN had greater CO compared to lean PHTN (6.3 +/- 1 vs 4.7 +/- 1 L/min-1, P = 0.005) and decreased SVR compared to lean PHTN (1218 +/- 263 vs 1606 +/- 444 Dyn.s/cm5, P = 0.003). Average 60-minute post-exercise brachial and central SBP reduced by 3 mm Hg in Lean PHTN in response to acute exercise (P < 0.005), while significantly increasing 4 mm Hg for brachial and 3 mm Hg for central SBP (P < 0.05). SVR had a significantly greater reduction following acute exercise in lean PHTN (-223 Dyn&dot;s/cm 5) compared to obese PHTN (-75 Dyn&dot;s/cm5, P < 0.001). In lean subjects chronic training reduced brachial BP by 4 mm Hg and central BP by 3 mm Hg but training had no effect on the BP's in obese subjects. Resting BP reduction in response to training was accompanied by reductions in SVR within lean (-169 Dyn&dot;s/cm5, P < 0.001), while obese experienced increased SVR following training (47 Dyn&dot;s/cm 5, P < 0.001). CONCLUSION: Hemodynamic response to both acute and chronic exercise training differ between obese and lean individuals.

ISBN: 9781339714356Subjects--Topical Terms:

518431
Physiology.

Comparison of Hemodynamic Responses to Acute and Chronic Exercise in Obese and Lean Prehypertensive Men.
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520 $a PURPOSE: Lean hypertension (HTN) is characterized by a mechanistically different HTN when compared to obese HTN. The purpose of this study is to assess whether body phenotype influences blood pressure (BP) responses following both acute and chronic exercise. METHODS: Obese (body mass index (BMI) > 30 kg/m2) and lean (BMI < 25 kg/m2) men with pre-hypertension (PHTN) (systolic BP (SBP) 120--139 or diastolic BP (DBP) 80--89 mm Hg) were asked to participate in a two-phase trial. Phase 1 assessed differences in post-exercise hypotension between groups in response to an acute exercise bout. Phase 2 consisted of a two-week aerobic exercise intervention at 65--70% of heart rate (HR) max on a cycle ergometer. Primary outcome measures were: brachial BP, central (aortic) BP, cardiac output (CO), and systemic vascular resistance (SVR) measured acutely after one exercise session and following two weeks of training. RESULTS: There were no differences between groups for baseline resting brachial BP, central BP, age, or VO 2 peak (all P > 0.05). At rest, obese PHTN had greater CO compared to lean PHTN (6.3 +/- 1 vs 4.7 +/- 1 L/min-1, P = 0.005) and decreased SVR compared to lean PHTN (1218 +/- 263 vs 1606 +/- 444 Dyn.s/cm5, P = 0.003). Average 60-minute post-exercise brachial and central SBP reduced by 3 mm Hg in Lean PHTN in response to acute exercise (P < 0.005), while significantly increasing 4 mm Hg for brachial and 3 mm Hg for central SBP (P < 0.05). SVR had a significantly greater reduction following acute exercise in lean PHTN (-223 Dyn&dot;s/cm 5) compared to obese PHTN (-75 Dyn&dot;s/cm5, P < 0.001). In lean subjects chronic training reduced brachial BP by 4 mm Hg and central BP by 3 mm Hg but training had no effect on the BP's in obese subjects. Resting BP reduction in response to training was accompanied by reductions in SVR within lean (-169 Dyn&dot;s/cm5, P < 0.001), while obese experienced increased SVR following training (47 Dyn&dot;s/cm 5, P < 0.001). CONCLUSION: Hemodynamic response to both acute and chronic exercise training differ between obese and lean individuals.
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