東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

A CMOS compatible optical biosensing...

Yan, Rongjin.

Linked to FindBook

Google Book

Amazon

博客來

A CMOS compatible optical biosensing system based on local evanescent field shift mechanism.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A CMOS compatible optical biosensing system based on local evanescent field shift mechanism./
Author:	Yan, Rongjin.
Description:	196 p.
Notes:	Source: Dissertation Abstracts International, Volume: 73-04, Section: B, page: 2420.
Contained By:	Dissertation Abstracts International73-04B.
Subject:	Electrical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3489944
ISBN:	9781267098238

A CMOS compatible optical biosensing system based on local evanescent field shift mechanism.
Yan, Rongjin.

A CMOS compatible optical biosensing system based on local evanescent field shift mechanism. - 196 p.

Source: Dissertation Abstracts International, Volume: 73-04, Section: B, page: 2420.

Thesis (Ph.D.)--Colorado State University, 2011.

This item is not available from ProQuest Dissertations & Theses.

The need for label-free integrated optical biosensors has dramatically increased in recent years. Integrated optical biosensors have many advantages, including low-cost, and portability. They can be applied to many fields, including clinical diagnostics, food safety, environmental monitoring, and biosecurity applications. One of the most important applications is point-of-care diagnosis, which means the disease could be tested at or near the site of patient care rather than in a laboratory.

ISBN: 9781267098238Subjects--Topical Terms:

649834
Electrical engineering.

A CMOS compatible optical biosensing system based on local evanescent field shift mechanism.
LDR:06020nmm a2200373 4500 001 2073113
005 20160914074005.5
008 170521s2011 ||||||||||||||||| ||eng d
020 $a 9781267098238
035 $a (MiAaPQ)AAI3489944
035 $a AAI3489944
040 $a MiAaPQ $c MiAaPQ
100 1 $a Yan, Rongjin. $3 3188340
245 1 2 $a A CMOS compatible optical biosensing system based on local evanescent field shift mechanism.
300 $a 196 p.
500 $a Source: Dissertation Abstracts International, Volume: 73-04, Section: B, page: 2420.
500 $a Adviser: Kevin L. Lear.
502 $a Thesis (Ph.D.)--Colorado State University, 2011.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a The need for label-free integrated optical biosensors has dramatically increased in recent years. Integrated optical biosensors have many advantages, including low-cost, and portability. They can be applied to many fields, including clinical diagnostics, food safety, environmental monitoring, and biosecurity applications. One of the most important applications is point-of-care diagnosis, which means the disease could be tested at or near the site of patient care rather than in a laboratory.
520 $a We are exploring the issues of design, modeling and measurement of a novel chip-scale local evanescent array coupled (LEAC) biosensor, which is an ideal platform for point-of-care diagnosis.
520 $a Until now, three generations of LEAC samples have been designed, fabricated and tested. The 1st generation of LEAC sensor without a buried detector array was characterized using a commercial near field scanning optical microscope (NSOM). The sample was polished and was end-fire light coupled using single mode fiber. The field shift mechanism in this proof-to-concept configuration without buried detector arrays has been validated with inorganic adlayers[1], photoresist[2] and different concentrations of CRP proteins[3]. Mode beating phenomena was predicted by the beam propagation method (BPM) and was observed in the NSOM measurement.
520 $a A 2nd generation LEAC sensor with a buried detector array was fabricated using 0.35&mgr;m CMOS process at the Avogo Technologies Inc., Fort Collins, Colorado. Characterizations with both single layer patternings, including photoresist as well as BSA [4] and immunoassay complexes [5] were done with cooperative efforts from various research groups. The BPM method was used to study the LEAC sensor, and the simulation results demonstrated the sensitivity of the LEAC sensor is 16%/nm, which was proved to match well with the experimental data [6]. Different antigen/antibodies, including mouse IgG and Hspx (a tuberculosis reactive antigen), have been used to test the immunoassay ability of LEAC sensor [7].
520 $a Many useful data have been collected by using the 2nd generation LEAC chip. However, during the characterization of the Avago chips, some design problems were revealed, including incompatibility with microfluidic integration, restricted detection region, strong sidewall scattering and uncoupled light interference from the single mode fiber. To address these problems, the 3rd generation LEAC sensor chip with buried detector arrays was designed to allow real-time monitoring and compatibility with microfluidic channel integration. 3rd generation samples have been fabricated in the CSU cleanroom and the mesa detector structure has been replaced with the thin insulator detector structure to solve the problems encountered during the characterizations. PDMS microfluidic channels and a multichannel measurement system consisting of a probe card, a multiplexing/amplification circuit and a LabVIEW program have been implemented into the LEAC system.
520 $a In recent years, outbreaks of fast spreading viral diseases, such as bird flu and H1N1, have drawn a lot of concern of the point-of-care virus detection techniques. To test the virus detection ability of LEAC sensor, 40nm and 200nm polystyrene nanoparticles were immobilized onto the waveguide, and the increased scattered light was collected. Sensitivities of 1%/particle and 0.04%/particle were observed for 200nm and 40nm particles respectively.
520 $a References: [1] G. Yuan, M. Stephens, D. Dandy, and K. Lear, "Direct imaging of transient interference in a single-mode waveguide using near-field scanning optical microscopy," IEEE Photonics Technology Letters, vol. 17, Nov. 2005, pp. 2382-2384. [2] G. Yuan, M. Stephens, D.S. Dandy, and K.L. Lear, "Local Evanescent, Array Coupled (LEAC) Biosensor Response to Low Index Adlayers," Conference on Lasers and Electro-Optics (CLEO), CThL, 2006. [3] R. Yan, G. Yuan, M.D. Stephens, X. He, C.S. Henry, D.S. Dandy, and K.L. Lear, "Evanescent field response to immunoassay layer thickness on planar waveguides," Applied Physics Letters, vol. 93, 2008, pp. 101110-3. [4] R. Yan, S.P. Mestas, G. Yuan, R. Safaisini, D.S. Dandy, and K.L. Lear, "Label-free silicon photonic biosensor system with integrated detector array," Lab on a Chip, vol. 9, 2009, pp. 2163-2168. [5] R. Yan, L. Kingry, R. Slayden, and K. Lear, "Demonstration of the immunoassay using local evanescent array coupled biosensor," SPIE Photonic West 2010, 2010, 7559-14. [6] R. Yan, S.P. Mestas, G. Yuan, R. Safaisini, and K.L. Lear, "Response of Local Evanescent Array-Coupled Biosensors to Organic Nanofilms," Journal of Selected Topics in Quantum Electronics, vol. 15, 2009, pp. 1469-1477. [7] R. Yan, N.S. Lynn, L.C. Kingry, Z. Yi, R.A. Slayden, D.S. Dandy and K.L. Lear, "Waveguide biosensor with integrated detector array for tuberculosis testing," Applied Physics Letters, vol. 98, 2010, pp. 013702.
590 $a School code: 0053.
650 4 $a Electrical engineering. $3 649834
650 4 $a Biomedical engineering. $3 535387
650 4 $a Optics. $3 517925
690 $a 0544
690 $a 0541
690 $a 0752
710 2 $a Colorado State University. $b Electrical & Computer Engineering. $3 3185822
773 0 $t Dissertation Abstracts International $g 73-04B.
790 $a 0053
791 $a Ph.D.
792 $a 2011
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3489944