東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Development of multifunctional and e...

Cao, Bin.

FindBook

Google Book

Amazon

博客來

Development of multifunctional and electrical conducting carboxybetaine based polymers.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Development of multifunctional and electrical conducting carboxybetaine based polymers./
作者:	Cao, Bin.
面頁冊數:	166 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
Contained By:	Dissertation Abstracts International76-11B(E).
標題:	Chemical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3710106
ISBN:	9781321859478

Development of multifunctional and electrical conducting carboxybetaine based polymers.
Cao, Bin.

Development of multifunctional and electrical conducting carboxybetaine based polymers. - 166 p.

Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.

Thesis (Ph.D.)--The University of Akron, 2015.

This dissertation describes the design and development of three novel multifunctional carboxybetaine (CB) based zwitterionic polymer platforms, which integrate superior antifouling property, enhanced mechanical property, switchable antimicrobial property and electrical conductivity.

ISBN: 9781321859478Subjects--Topical Terms:

560457
Chemical engineering.

Development of multifunctional and electrical conducting carboxybetaine based polymers.
LDR:04153nmm a2200301 4500 001 2071374
005 20160708094654.5
008 170521s2015 ||||||||||||||||| ||eng d
020 $a 9781321859478
035 $a (MiAaPQ)AAI3710106
035 $a AAI3710106
040 $a MiAaPQ $c MiAaPQ
100 1 $a Cao, Bin. $3 2195124
245 1 0 $a Development of multifunctional and electrical conducting carboxybetaine based polymers.
300 $a 166 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
500 $a Adviser: Gang Cheng.
502 $a Thesis (Ph.D.)--The University of Akron, 2015.
520 $a This dissertation describes the design and development of three novel multifunctional carboxybetaine (CB) based zwitterionic polymer platforms, which integrate superior antifouling property, enhanced mechanical property, switchable antimicrobial property and electrical conductivity.
520 $a In the first zwitterionic biomaterial platform, the switchable multifunctional polymers with integrated antimicrobial and antifouling properties were developed. The side chains of hydroxyethyl functionalized CB derivatives could reversely switch between a cationic ring form and a zwitterionic form by changing acidic and basic conditions. Nuclear magnetic resonance (NMR) method was employed to confirm the ring structure formation and monitor the dynamic ring switching process. In the ring form, cationic polymeric surfaces could catch and kill the attached bacteria; in the zwitterionic form, the surfaces released killed bacterial cells, and resisted protein adsorption and bacterial attachment. The hydrogels of hydroxyethyl functionalized CB derivatives also showed dramatically improved mechanical properties, which are highly desired for biomedical applications. In a follow-up work, a systematic study was carried out to understand how the structure of zwitterionic materials affected their elasticity, switchability, stability and antifouling properties. This study provides a general design guideline for the development of new zwitterionic materials in many biomedical applications.
520 $a In the second zwitterionic biomaterial platform, a facile one-pot zwitteration method was developed to synthesize biodegradable zwitterionic polysaccharides. Dextran was selected as a model polymer. Cell attachment and protein adsorption studies were carried out on hydrogels made of dextrans with various degrees of the CB substitution. NMR method was applied to confirm the ring structure formation and monitor the dynamic ring switching process of the carboxybetaine-dextran (CB-Dex). It was demonstrated that the zwitteration with CB groups endows dextran superior antifouling property, switchability and enhanced optical transparency. This work has shed light on ingenious designing of zwitterionic material and provided a new avenue of generating high performance multifunctional polysaccharides.
520 $a In the last zwitterionic biomaterial platform, the zwitterionic conjugated polymers, which contain a conducting polythiophene backbone and multifunctional side chains, were developed. Cell attachment study showed that a controllable antifouling property could be simply achieved through grafting specific peptides onto the readily available reactive sites. Zwitterionic materials gained electrical conductivity and optical properties through the conjugated polymer backbone, and the non-biocompatible conjugated polymer obtained excellent antifouling properties, enhanced electrical conductivity, functional groups of bioconjugation and response to environmental stimuli via multifunctional zwitterionic side chains. This platform can potentially be adapted to a wide range of applications (e.g. bioelectronics, tissue engineering and biofuel cell), which require high performance conducting materials with excellent antifouling/biocompatibility at biointerfaces.
590 $a School code: 0003.
650 4 $a Chemical engineering. $3 560457
690 $a 0542
710 2 $a The University of Akron. $b Chemical Engineering. $3 2094126
773 0 $t Dissertation Abstracts International $g 76-11B(E).
790 $a 0003
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3710106