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Cost-utility analysis of medications...

Pistoresi, Ryan.

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Cost-utility analysis of medications for relapsing-remitting multiple sclerosis: A United States third-party payer perspective.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Cost-utility analysis of medications for relapsing-remitting multiple sclerosis: A United States third-party payer perspective./
Author:	Pistoresi, Ryan.
Description:	36 p.
Notes:	Source: Masters Abstracts International, Volume: 55-01.
Contained By:	Masters Abstracts International55-01(E).
Subject:	Pharmaceutical sciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1600453
ISBN:	9781339090238

Cost-utility analysis of medications for relapsing-remitting multiple sclerosis: A United States third-party payer perspective.
Pistoresi, Ryan.

Cost-utility analysis of medications for relapsing-remitting multiple sclerosis: A United States third-party payer perspective. - 36 p.

Source: Masters Abstracts International, Volume: 55-01.

Thesis (M.S.)--University of Washington, 2015.

Background: Many new disease-modifying therapies (DMTs) have recently been approved for relapsing-remitting multiple sclerosis (RRMS) in the United States. Objective: To assess the values of 10 first-line therapies for RRMS, including generic glatiramer acetate, versus the natural history of disease for a newly diagnosed RRMS patient. Perspective: United States third-party payer. Methods: A Markov model was developed and estimates were made using data on natural history of disease progression, annual relapse rates, medication efficacy, costs, and utilities to determine incremental cost-effectiveness ratios (ICERs). Results: Base case is a cohort of 30-year-old females at Extended Disability Status Scale (EDSS) state 0 at a 20 year time horizon versus the natural history of disease. Dimethyl fumarate demonstrates the lowest ICER at $895,073/QALY. Conclusions: DMTs for RRMS have low value versus the natural history of disease, and would not be considered cost-effective by conventional standards.

ISBN: 9781339090238Subjects--Topical Terms:

3173021
Pharmaceutical sciences.

Cost-utility analysis of medications for relapsing-remitting multiple sclerosis: A United States third-party payer perspective.
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500 $a Source: Masters Abstracts International, Volume: 55-01.
500 $a Adviser: Louis P. Garrison.
502 $a Thesis (M.S.)--University of Washington, 2015.
520 $a Background: Many new disease-modifying therapies (DMTs) have recently been approved for relapsing-remitting multiple sclerosis (RRMS) in the United States. Objective: To assess the values of 10 first-line therapies for RRMS, including generic glatiramer acetate, versus the natural history of disease for a newly diagnosed RRMS patient. Perspective: United States third-party payer. Methods: A Markov model was developed and estimates were made using data on natural history of disease progression, annual relapse rates, medication efficacy, costs, and utilities to determine incremental cost-effectiveness ratios (ICERs). Results: Base case is a cohort of 30-year-old females at Extended Disability Status Scale (EDSS) state 0 at a 20 year time horizon versus the natural history of disease. Dimethyl fumarate demonstrates the lowest ICER at $895,073/QALY. Conclusions: DMTs for RRMS have low value versus the natural history of disease, and would not be considered cost-effective by conventional standards.
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