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The Effects of Hypoxia on Centrosome...

Taiakina, Daria.

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The Effects of Hypoxia on Centrosome Function in Prostate Cancer.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Effects of Hypoxia on Centrosome Function in Prostate Cancer./
Author:	Taiakina, Daria.
Description:	94 p.
Notes:	Source: Masters Abstracts International, Volume: 55-02.
Contained By:	Masters Abstracts International55-02(E).
Subject:	Cellular biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1604604
ISBN:	9781339282633

The Effects of Hypoxia on Centrosome Function in Prostate Cancer.
Taiakina, Daria.

The Effects of Hypoxia on Centrosome Function in Prostate Cancer. - 94 p.

Source: Masters Abstracts International, Volume: 55-02.

Thesis (M.Sc.)--University of Toronto (Canada), 2015.

Hypoxia and centrosome aberrations are both prominent features of prostate cancer and have been shown to be markers of poor clinical prognosis. Hypoxia has been linked to increased genomic instability and aggressive tumor phenotype. Centrosome aberrations have also been directly linked to chromosomal instability. I hypothesized that hypoxia causes centrosome aberrations in prostate cancer cells, as a potential mechanism of hypoxia-induced genomic instability. Analyses of centrosome gene expression in DU14 prostate cancer cells demonstrated that hypoxia causes centrosome gene deregulation. Centrosome structure assays revealed that hypoxia leads to accumulation of centriolar satellites in a cell line and re-oxygenation independent manner. If centrosome aberrations are specific to hypoxic cancer cells, centrosome and mitosis targeting drugs could provide a high therapeutic ratio and better outcome for patients with high hypoxic tumor fraction.

ISBN: 9781339282633Subjects--Topical Terms:

3172791
Cellular biology.

The Effects of Hypoxia on Centrosome Function in Prostate Cancer.
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100 1 $a Taiakina, Daria. $3 3181599
245 1 4 $a The Effects of Hypoxia on Centrosome Function in Prostate Cancer.
300 $a 94 p.
500 $a Source: Masters Abstracts International, Volume: 55-02.
500 $a Adviser: Robert G. Bristow.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2015.
520 $a Hypoxia and centrosome aberrations are both prominent features of prostate cancer and have been shown to be markers of poor clinical prognosis. Hypoxia has been linked to increased genomic instability and aggressive tumor phenotype. Centrosome aberrations have also been directly linked to chromosomal instability. I hypothesized that hypoxia causes centrosome aberrations in prostate cancer cells, as a potential mechanism of hypoxia-induced genomic instability. Analyses of centrosome gene expression in DU14 prostate cancer cells demonstrated that hypoxia causes centrosome gene deregulation. Centrosome structure assays revealed that hypoxia leads to accumulation of centriolar satellites in a cell line and re-oxygenation independent manner. If centrosome aberrations are specific to hypoxic cancer cells, centrosome and mitosis targeting drugs could provide a high therapeutic ratio and better outcome for patients with high hypoxic tumor fraction.
590 $a School code: 0779.
650 4 $a Cellular biology. $3 3172791
650 4 $a Molecular biology. $3 517296
650 4 $a Canadian history. $3 3174996
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710 2 $a University of Toronto (Canada). $b Medical Biophysics. $3 3181600
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1604604