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Biological and biologically inspired...

Paslay, Lea Clayton.

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Biological and biologically inspired polymers for interface modification.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Biological and biologically inspired polymers for interface modification./
Author:	Paslay, Lea Clayton.
Description:	139 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-09(E), Section: B.
Contained By:	Dissertation Abstracts International74-09B(E).
Subject:	Polymer chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3569767
ISBN:	9781303072864

Biological and biologically inspired polymers for interface modification.
Paslay, Lea Clayton.

Biological and biologically inspired polymers for interface modification. - 139 p.

Source: Dissertation Abstracts International, Volume: 74-09(E), Section: B.

Thesis (Ph.D.)--The University of Southern Mississippi, 2013.

Naturally occurring macromolecules are produced for a specific function and have the selectivity to accomplish objectives with little waste in energy. The scientific community strives to develop smart, efficient molecules on an economical scale, thus lessons can be learned from nature and applied to cost effective synthetic systems. First, the mimicry of naturally occurring antimicrobial peptides (AMPs) will be described. AMPs show great potential as alternatives to conventional antibiotics as they can selectively bind and eliminate pathogenic bacteria without harming eukaryotic tissues. Aqueous reversible addition--fragmentation chain transfer (RAFT) polymerization was utilized to prepare primary and tertiary amine containing AMP polymer mimics with precise polymerization control. The detailed synthetic strategy along with an outline of in vitro cell studies will be discussed in order to elucidate the effect of polymer composition on antimicrobial activity and selectivity.

ISBN: 9781303072864Subjects--Topical Terms:

3173488
Polymer chemistry.

Biological and biologically inspired polymers for interface modification.
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020 $a 9781303072864
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100 1 $a Paslay, Lea Clayton. $3 3180152
245 1 0 $a Biological and biologically inspired polymers for interface modification.
300 $a 139 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-09(E), Section: B.
500 $a Adviser: Sarah E. Morgan.
502 $a Thesis (Ph.D.)--The University of Southern Mississippi, 2013.
520 $a Naturally occurring macromolecules are produced for a specific function and have the selectivity to accomplish objectives with little waste in energy. The scientific community strives to develop smart, efficient molecules on an economical scale, thus lessons can be learned from nature and applied to cost effective synthetic systems. First, the mimicry of naturally occurring antimicrobial peptides (AMPs) will be described. AMPs show great potential as alternatives to conventional antibiotics as they can selectively bind and eliminate pathogenic bacteria without harming eukaryotic tissues. Aqueous reversible addition--fragmentation chain transfer (RAFT) polymerization was utilized to prepare primary and tertiary amine containing AMP polymer mimics with precise polymerization control. The detailed synthetic strategy along with an outline of in vitro cell studies will be discussed in order to elucidate the effect of polymer composition on antimicrobial activity and selectivity.
520 $a The second section of this work will discuss a highly surface active protein from filamentous fungi called hydrophobin. Hydrophobins are small proteins that spontaneously self-assemble into polymeric films at interfaces. They are amphipathic in nature and form tightly bound membranes that shift the polarity of interfaces at which they assemble. This research focuses on elucidating the mechanisms and driving forces for assembly of the ABH1 hydrophobin protein from the edible white button mushroom Agaricus bisporus..
590 $a School code: 0211.
650 4 $a Polymer chemistry. $3 3173488
650 4 $a Chemistry. $3 516420
650 4 $a Biochemistry. $3 518028
690 $a 0495
690 $a 0485
690 $a 0487
710 2 $a The University of Southern Mississippi. $b Polymers and High Performance Materials. $3 3180153
773 0 $t Dissertation Abstracts International $g 74-09B(E).
790 $a 0211
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3569767