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Comparing Virus Ultrafiltration of B...

Smith, Kent.

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Comparing Virus Ultrafiltration of Bacteriophages with Filtration of Minute Virus of Mice.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Comparing Virus Ultrafiltration of Bacteriophages with Filtration of Minute Virus of Mice./
Author:	Smith, Kent.
Description:	34 p.
Notes:	Source: Masters Abstracts International, Volume: 52-06.
Contained By:	Masters Abstracts International52-06(E).
Subject:	Chemical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1554640
ISBN:	9781303857096

Comparing Virus Ultrafiltration of Bacteriophages with Filtration of Minute Virus of Mice.
Smith, Kent.

Comparing Virus Ultrafiltration of Bacteriophages with Filtration of Minute Virus of Mice. - 34 p.

Source: Masters Abstracts International, Volume: 52-06.

Thesis (M.S.Ch.E.)--University of Arkansas, 2014.

This item must not be sold to any third party vendors.

Industrial production of protein therapeutics demand rigorous testing and clearance of viruses. The U.S. Food and Drug Administration dictate the purity of pharmaceuticals with regards to viral contamination. As this testing is time consuming and expensive using mammalian cells and viruses, bacteriophages may provide a faster and cheaper alternative for membrane filtration processes. We used ultrafiltration membranes to filter protein solutions with viruses. Two bacteriophages were tested against membranes with two different pore sizes. These membranes were then tested by inverting the membrane's orientation. Flux measurements and log virus removal data were taken. Flux and log virus removal were seen to be slightly higher than published data for mammalian virus analogue minute virus of mice. Future testing would allow for more precise evaluation, but data suggests bacteriophages provide similar results to mammalian data.

ISBN: 9781303857096Subjects--Topical Terms:

560457
Chemical engineering.

Comparing Virus Ultrafiltration of Bacteriophages with Filtration of Minute Virus of Mice.
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245 1 0 $a Comparing Virus Ultrafiltration of Bacteriophages with Filtration of Minute Virus of Mice.
300 $a 34 p.
500 $a Source: Masters Abstracts International, Volume: 52-06.
500 $a Adviser: Sumith Ranil Wickramasinghe.
502 $a Thesis (M.S.Ch.E.)--University of Arkansas, 2014.
506 $a This item must not be sold to any third party vendors.
520 $a Industrial production of protein therapeutics demand rigorous testing and clearance of viruses. The U.S. Food and Drug Administration dictate the purity of pharmaceuticals with regards to viral contamination. As this testing is time consuming and expensive using mammalian cells and viruses, bacteriophages may provide a faster and cheaper alternative for membrane filtration processes. We used ultrafiltration membranes to filter protein solutions with viruses. Two bacteriophages were tested against membranes with two different pore sizes. These membranes were then tested by inverting the membrane's orientation. Flux measurements and log virus removal data were taken. Flux and log virus removal were seen to be slightly higher than published data for mammalian virus analogue minute virus of mice. Future testing would allow for more precise evaluation, but data suggests bacteriophages provide similar results to mammalian data.
590 $a School code: 0011.
650 4 $a Chemical engineering. $3 560457
650 4 $a Biomedical engineering. $3 535387
650 4 $a Virology. $3 642304
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710 2 $a University of Arkansas. $b Chemical Engineering. $3 3178318
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