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Characterizing the biochemical and t...

Massarsky, Andrey.

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Characterizing the biochemical and toxicological effects of nanosilver in vivo using zebrafish (Danio rerio) and in vitro using rainbow trout (Oncorhynchus mykiss).

Record Type:	Electronic resources : Monograph/item
Title/Author:	Characterizing the biochemical and toxicological effects of nanosilver in vivo using zebrafish (Danio rerio) and in vitro using rainbow trout (Oncorhynchus mykiss)./
Author:	Massarsky, Andrey.
Description:	246 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-07(E), Section: B.
Contained By:	Dissertation Abstracts International75-07B(E).
Subject:	Cellular biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NS28510
ISBN:	9780499285102

Characterizing the biochemical and toxicological effects of nanosilver in vivo using zebrafish (Danio rerio) and in vitro using rainbow trout (Oncorhynchus mykiss).
Massarsky, Andrey.

Characterizing the biochemical and toxicological effects of nanosilver in vivo using zebrafish (Danio rerio) and in vitro using rainbow trout (Oncorhynchus mykiss). - 246 p.

Source: Dissertation Abstracts International, Volume: 75-07(E), Section: B.

Thesis (Ph.D.)--University of Ottawa (Canada), 2014.

This item must not be sold to any third party vendors.

Many consumer and medical products contain engineered nanomaterials (ENMs) due to their unique properties arising from their small size of <100 nm in at least one dimension. Although ENMs could greatly improve the quality of daily life, concerns for their health and environmental safety emerged in recent years because the same properties that make ENMs beneficial may also render them toxic. The small size allows ENMs' entrance into the cell where they may attach to biological molecules and membranes, disrupting their function and/or leading to oxidative stress and/or damage.

ISBN: 9780499285102Subjects--Topical Terms:

3172791
Cellular biology.

Characterizing the biochemical and toxicological effects of nanosilver in vivo using zebrafish (Danio rerio) and in vitro using rainbow trout (Oncorhynchus mykiss).
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100 1 $a Massarsky, Andrey. $3 3175895
245 1 0 $a Characterizing the biochemical and toxicological effects of nanosilver in vivo using zebrafish (Danio rerio) and in vitro using rainbow trout (Oncorhynchus mykiss).
300 $a 246 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-07(E), Section: B.
500 $a Advisers: Thomas W. Moon; Vance L. Trudeau.
502 $a Thesis (Ph.D.)--University of Ottawa (Canada), 2014.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a Many consumer and medical products contain engineered nanomaterials (ENMs) due to their unique properties arising from their small size of <100 nm in at least one dimension. Although ENMs could greatly improve the quality of daily life, concerns for their health and environmental safety emerged in recent years because the same properties that make ENMs beneficial may also render them toxic. The small size allows ENMs' entrance into the cell where they may attach to biological molecules and membranes, disrupting their function and/or leading to oxidative stress and/or damage.
520 $a This thesis focused on silver nanoparticles (AgNPs). Several articles demonstrated that during washing AgNPs are released from the AgNP-impregnated fabrics and could pose a risk to aquatic species. Given that the toxicity mechanisms of AgNPs are yet to be clearly understood this thesis investigated the effects of AgNPs from 'oxidative stress' and 'endocrine disruption' points of view, using both in vivo and in vitro model fish systems.
520 $a A 4 d exposure of zebrafish (Danio rerio) embryos to AgNPs increased mortality, delayed hatching, and increased oxidative stress. The silver ion (Ag+) was more effective in eliciting these effects at equivalent silver concentrations. Moreover, the Ag-chelator cysteine reduced the toxicity of both Ag-types. Despite these effects AgNPs or Ag + did not affect the ability of zebrafish larvae or adults (raised to adulthood in Ag-free water) to increase cortisol levels, but there were differential effects on the expression of corticotropin-releasing factor (CRF)-related genes, suggesting that other physiological processes regulated by CRF may be impacted.
520 $a Furthermore, a 48 h exposure of rainbow trout (Oncorhynchus mykiss ) erythrocytes and hepatocytes to AgNPs or Ag+ increased oxidative stress, but Ag+ was more potent. Moreover, AgNPs elevated lipid peroxidation, while Ag+ increased DNA damage, suggesting different modes of action for the two Ag-types. Cysteine treatment reduced the toxicity of Ag+ and AgNPs, while buthionine sulfoximine, which inhibits glutathione synthesis, increased it, suggesting the importance of glutathione in silver toxicity. Finally, AgNPs increased glycogenolysis in trout hepatocytes independently of the beta-adrenoreceptor or the glucocorticoid receptor.
590 $a School code: 0918.
650 4 $a Cellular biology. $3 3172791
650 4 $a Environmental health. $3 543032
650 4 $a Aquatic sciences. $3 3174300
650 4 $a Nanoscience. $3 587832
650 4 $a Toxicology. $3 556884
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690 $a 0470
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710 2 $a University of Ottawa (Canada). $b Biology. $3 2049968
773 0 $t Dissertation Abstracts International $g 75-07B(E).
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791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NS28510