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Regional differences in brain struct...

Chang, Soo-Eun.

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Regional differences in brain structure underlying childhood stuttering persistence and recovery: An MRI study.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Regional differences in brain structure underlying childhood stuttering persistence and recovery: An MRI study./
Author:	Chang, Soo-Eun.
Description:	146 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6569.
Contained By:	Dissertation Abstracts International66-12B.
Subject:	Health Sciences, Speech Pathology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3198940
ISBN:	9780542445682

Regional differences in brain structure underlying childhood stuttering persistence and recovery: An MRI study.
Chang, Soo-Eun.

Regional differences in brain structure underlying childhood stuttering persistence and recovery: An MRI study. - 146 p.

Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6569.

Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.

This item must not be sold to any third party vendors.

The cause of stuttering remains unknown. Several studies indicate the presence of subtle differences in neurophysiological function and structure in adults who stutter (AWS) compared to normally fluent controls, supporting past hypotheses of aberrant speech motor and sensory function related to stuttering. To date, such findings have not been replicated in children, although stuttering starts and more often than not resolves on its own during childhood. The mechanisms of stuttering persistence and recovery can best be revealed through investigating children, as they are less likely to exhibit structural/functional differences due to the possible effects of years dealing with their speech deficit, common in AWS.

ISBN: 9780542445682Subjects--Topical Terms:

1018105
Health Sciences, Speech Pathology.

Regional differences in brain structure underlying childhood stuttering persistence and recovery: An MRI study.
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020 $a 9780542445682
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100 1 $a Chang, Soo-Eun. $3 3171534
245 1 0 $a Regional differences in brain structure underlying childhood stuttering persistence and recovery: An MRI study.
300 $a 146 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6569.
500 $a Adviser: Nicoline G. Ambrose.
502 $a Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a The cause of stuttering remains unknown. Several studies indicate the presence of subtle differences in neurophysiological function and structure in adults who stutter (AWS) compared to normally fluent controls, supporting past hypotheses of aberrant speech motor and sensory function related to stuttering. To date, such findings have not been replicated in children, although stuttering starts and more often than not resolves on its own during childhood. The mechanisms of stuttering persistence and recovery can best be revealed through investigating children, as they are less likely to exhibit structural/functional differences due to the possible effects of years dealing with their speech deficit, common in AWS.
520 $a In this study, subtle volumetric differences in brain white and gray matter (wm, gm) in three groups of children differing in stuttering status (children with persistent developmental stuttering (CWPS), those recovered naturally from stuttering (CWRS), and normally fluent children (CWNS)) were compared with voxel-based morphometry (VBM), an unbiased, whole-brain based morphometric MRI technique. Results show interesting differences in wm, gm volume in several regions in the brain that differentiate the three groups.
520 $a CWPS and CWRS exhibited similar structural anomalies when contrasted to CWNS in several cortical, subcortical, and cerebellar regions critical for speech motor sequencing and sensorimotor integration, such as the left inferior frontal area, bilateral temporoparietal regions, as well as several areas in the basal ganglia and thalamus. When CWPS and CWRS were compared, the latter often exhibited intermediate tissue volume compared to the other two groups in the regions noted above. Results point to a structural basis for stuttering that is likely associated with inefficient function of cortical, subcortical, and cerebellar structures that normally work together in a coordinated fashion to achieve timely and efficient sensorimotor processing. Stuttering recovery, on the other hand, appears to involve maturation of these structures to resemble tissue growth in normally fluent children, enabling normalization of sensorimotor function, and hence, fluent speech production.
590 $a School code: 0090.
650 4 $a Health Sciences, Speech Pathology. $3 1018105
690 $a 0460
710 2 $a University of Illinois at Urbana-Champaign. $3 626646
773 0 $t Dissertation Abstracts International $g 66-12B.
790 $a 0090
791 $a Ph.D.
792 $a 2005
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3198940