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The electrospray: Fundamentals and f...

Tang, Keqi.

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The electrospray: Fundamentals and feasibility of its application to targeted drug delivery by inhalation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The electrospray: Fundamentals and feasibility of its application to targeted drug delivery by inhalation./
Author:	Tang, Keqi.
Description:	228 p.
Notes:	Source: Dissertation Abstracts International, Volume: 56-03, Section: B, page: 1494.
Contained By:	Dissertation Abstracts International56-03B.
Subject:	Physics, Fluid and Plasma. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9523240

The electrospray: Fundamentals and feasibility of its application to targeted drug delivery by inhalation.
Tang, Keqi.

The electrospray: Fundamentals and feasibility of its application to targeted drug delivery by inhalation. - 228 p.

Source: Dissertation Abstracts International, Volume: 56-03, Section: B, page: 1494.

Thesis (Ph.D.)--Yale University, 1994.

This item must not be sold to any third party vendors.

A comprehensive investigation has been performed on the principal features of a particular class of electrostatic sprays. Such electrospray can be established by feeding a liquid, with sufficient electric conductivity, into a small metal capillary maintained at several kilovolts relative to a ground electrode few centimeters away. The liquid meniscus at the outlet of the capillary takes a conical shape under the action of the electric field, through the apex of which a thin ligament is ejected. The ligament then breaks into monodisperse droplets for most of the mass flow ($\ge$97%). Droplet size measurements, using Phase Doppler Anemometry, showed that such sprays can be established in a broad size range with a typical ratio of standard deviation to mean droplet size of less than 10%. The liquid flow rate was shown to be a dominant fact for the control of the droplet size and the liquid electric conductivity a crucial parameter affecting the spray stability. Simultaneous measurements of both droplet size and charge showed that although droplet volume charge density decreases monotonically with the increase of droplet size, the larger droplets are closer to the Rayleigh limit at which they become unstable and disintegrate. Droplet coulombic fission was captured photographically. Measurements of droplet size, velocity and number density throughout the electrospray showed that both droplet velocity field and number density field are self-similar. Complementary use of these measurements and the spray momentum equation permitted the determination of the electric field in the electrospray. The calculations showed the relative importance of the space charge field and the external electric field between the two electrodes.Subjects--Topical Terms:

1018402
Physics, Fluid and Plasma.

The electrospray: Fundamentals and feasibility of its application to targeted drug delivery by inhalation.
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008 170521s1994 ||||||||||||||||| ||eng d
035 $a (MiAaPQ)AAI9523240
035 $a AAI9523240
040 $a MiAaPQ $c MiAaPQ
100 1 $a Tang, Keqi. $3 3170880
245 1 4 $a The electrospray: Fundamentals and feasibility of its application to targeted drug delivery by inhalation.
300 $a 228 p.
500 $a Source: Dissertation Abstracts International, Volume: 56-03, Section: B, page: 1494.
500 $a Adviser: Alessandro Gomez.
502 $a Thesis (Ph.D.)--Yale University, 1994.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a A comprehensive investigation has been performed on the principal features of a particular class of electrostatic sprays. Such electrospray can be established by feeding a liquid, with sufficient electric conductivity, into a small metal capillary maintained at several kilovolts relative to a ground electrode few centimeters away. The liquid meniscus at the outlet of the capillary takes a conical shape under the action of the electric field, through the apex of which a thin ligament is ejected. The ligament then breaks into monodisperse droplets for most of the mass flow ($\ge$97%). Droplet size measurements, using Phase Doppler Anemometry, showed that such sprays can be established in a broad size range with a typical ratio of standard deviation to mean droplet size of less than 10%. The liquid flow rate was shown to be a dominant fact for the control of the droplet size and the liquid electric conductivity a crucial parameter affecting the spray stability. Simultaneous measurements of both droplet size and charge showed that although droplet volume charge density decreases monotonically with the increase of droplet size, the larger droplets are closer to the Rayleigh limit at which they become unstable and disintegrate. Droplet coulombic fission was captured photographically. Measurements of droplet size, velocity and number density throughout the electrospray showed that both droplet velocity field and number density field are self-similar. Complementary use of these measurements and the spray momentum equation permitted the determination of the electric field in the electrospray. The calculations showed the relative importance of the space charge field and the external electric field between the two electrodes.
520 $a An experimental investigation was also performed on the feasibility of a particular application of the electrospray for targeted drug delivery by inhalation. Stable and monodisperse water sprays were successfully established with droplets in the diameter range of 2-10 $\mu$m by using a CO$\sb2$ sheath flow to raise the electric breakdown threshold of the host gas. A prototype delivery system was also developed and was shown to be in principle suitable for aerosol drug delivery.
590 $a School code: 0265.
650 4 $a Physics, Fluid and Plasma. $3 1018402
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0759
690 $a 0541
710 2 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 56-03B.
790 $a 0265
791 $a Ph.D.
792 $a 1994
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9523240