東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Polymeric micelles as a diagnostic t...

Hoang, Nu Bryan.

Linked to FindBook

Google Book

Amazon

博客來

Polymeric micelles as a diagnostic tool for image-guided drug delivery and radiotherapy of HER2 overexpressing breast cancer.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Polymeric micelles as a diagnostic tool for image-guided drug delivery and radiotherapy of HER2 overexpressing breast cancer./
Author:	Hoang, Nu Bryan.
Description:	221 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-11(E), Section: B.
Contained By:	Dissertation Abstracts International75-11B(E).
Subject:	Health Sciences, Pharmacy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3631329
ISBN:	9781321097740

Polymeric micelles as a diagnostic tool for image-guided drug delivery and radiotherapy of HER2 overexpressing breast cancer.
Hoang, Nu Bryan.

Polymeric micelles as a diagnostic tool for image-guided drug delivery and radiotherapy of HER2 overexpressing breast cancer. - 221 p.

Source: Dissertation Abstracts International, Volume: 75-11(E), Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2014.

This item must not be sold to any third party vendors.

Block copolymer micelles have emerged as a viable formulation strategy with several drugs relying on this technology in clinical evaluation. To date, information on the tumor penetration and intratumoral distribution of block copolymer micelles (BCM) has been quite limited. Thus, there is impetus to develop a radiolabeled formulation that can be used to gain invaluable insight into the intratumoral distribution of the BCMs. This information could then be used to direct formulation strategies as a means to optimize treatment outcomes.

ISBN: 9781321097740Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

Polymeric micelles as a diagnostic tool for image-guided drug delivery and radiotherapy of HER2 overexpressing breast cancer.
LDR:03342nmm a2200349 4500 001 2057020
005 20150630121440.5
008 170521s2014 ||||||||||||||||| ||eng d
020 $a 9781321097740
035 $a (MiAaPQ)AAI3631329
035 $a AAI3631329
040 $a MiAaPQ $c MiAaPQ
100 1 $a Hoang, Nu Bryan. $3 3170824
245 1 0 $a Polymeric micelles as a diagnostic tool for image-guided drug delivery and radiotherapy of HER2 overexpressing breast cancer.
300 $a 221 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-11(E), Section: B.
500 $a Advisers: Christine J. Allen; Raymond M. Reilly.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2014.
506 $a This item must not be sold to any third party vendors.
520 $a Block copolymer micelles have emerged as a viable formulation strategy with several drugs relying on this technology in clinical evaluation. To date, information on the tumor penetration and intratumoral distribution of block copolymer micelles (BCM) has been quite limited. Thus, there is impetus to develop a radiolabeled formulation that can be used to gain invaluable insight into the intratumoral distribution of the BCMs. This information could then be used to direct formulation strategies as a means to optimize treatment outcomes.
520 $a This thesis describes the synthesis and characterization of a targeted block copolymer micelle system based on poly(ethylene glycol)-block -poly(epsilon-caprolactone) labeled with the radionuclide Indium-111 (111In). The incorporation of the imageable component, 111In permits pursuit of image-guided drug delivery for real-time monitoring of tumor localization and intratumoral distribution. Intracellular trafficking of drugs and therapies such as Auger electron emitting radionuclides to perinuclear and nuclear regions of cells is critical to realizing their full therapeutic potential. HER2 specific antibodies (trastuzumab fab fragments) and nuclear localization signal peptides were conjugated to the surface of the BCMs to direct uptake in HER2 expressing cells and subsequent localization in the cell nucleus. Cell uptake was HER2 density dependent, confirming receptor-mediated internalization of the BCMs. Importantly, conjugation of NLS resulted in a significant increase in nuclear uptake of the radionuclide 111In. Successful nuclear targeting was shown to improve the antiproliferative effect of the Auger electrons. In addition, a significant radiation enhancement effect was observed by concurrent delivery of low-dose MTX and 111In in all breast cancer cell lines evaluated. Imaging enabled the accurate quantification of the specific tumor uptake of the micelles and visualization of their degree of tumor penetration in relation to microvessel density. Ultimately, the 111In-micelles could be used for such diverse applications as detection of malignancies, molecular characterization of tumors, improved therapy guidance and targeted anti-cancer treatment.
590 $a School code: 0779.
650 4 $a Health Sciences, Pharmacy. $3 1017737
650 4 $a Nanotechnology. $3 526235
650 4 $a Health Sciences, Oncology. $3 1018566
650 4 $a Women's Studies. $3 1017481
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0572
690 $a 0652
690 $a 0992
690 $a 0453
690 $a 0487
690 $a 0541
710 2 $a University of Toronto (Canada). $b Pharmaceutical Sciences. $3 3170825
773 0 $t Dissertation Abstracts International $g 75-11B(E).
790 $a 0779
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3631329