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Advancing techniques to promote the ...

Pairis-Garcia, Monique.

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Advancing techniques to promote the welfare of sows utilized in laboratory based lameness models.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Advancing techniques to promote the welfare of sows utilized in laboratory based lameness models./
Author:	Pairis-Garcia, Monique.
Description:	128 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-10(E), Section: B.
Contained By:	Dissertation Abstracts International75-10B(E).
Subject:	Agriculture, Animal Culture and Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3627443
ISBN:	9781321026894

Advancing techniques to promote the welfare of sows utilized in laboratory based lameness models.
Pairis-Garcia, Monique.

Advancing techniques to promote the welfare of sows utilized in laboratory based lameness models. - 128 p.

Source: Dissertation Abstracts International, Volume: 75-10(E), Section: B.

Thesis (Ph.D.)--Iowa State University, 2014.

The first objective for this dissertation was to refine and enhance common techniques conducted in a laboratory setting including drug administration, anesthesia and behavioral modification for laboratory housed sows to improve the welfare of sows specifically by minimizing pain and distress. The second objective of this dissertation was to use an optimal dosing regimen for two non-steroidal anti-inflammatory drugs to determine their efficacy in pain management using nociceptive threshold tests when sows are induced lame through the use of a chemical synovitis model. The expected outcome was that in this lameness pain model, the pain mitigation agents will alleviate pain as assessed by two nociceptive tests.

ISBN: 9781321026894Subjects--Topical Terms:

1017857
Agriculture, Animal Culture and Nutrition.

Advancing techniques to promote the welfare of sows utilized in laboratory based lameness models.
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020 $a 9781321026894
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100 1 $a Pairis-Garcia, Monique. $3 3169380
245 1 0 $a Advancing techniques to promote the welfare of sows utilized in laboratory based lameness models.
300 $a 128 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-10(E), Section: B.
500 $a Adviser: Anna Johnson.
502 $a Thesis (Ph.D.)--Iowa State University, 2014.
520 $a The first objective for this dissertation was to refine and enhance common techniques conducted in a laboratory setting including drug administration, anesthesia and behavioral modification for laboratory housed sows to improve the welfare of sows specifically by minimizing pain and distress. The second objective of this dissertation was to use an optimal dosing regimen for two non-steroidal anti-inflammatory drugs to determine their efficacy in pain management using nociceptive threshold tests when sows are induced lame through the use of a chemical synovitis model. The expected outcome was that in this lameness pain model, the pain mitigation agents will alleviate pain as assessed by two nociceptive tests.
520 $a For the first objective, I developed and refined a technique for catheter placement into the auricular vein of sows. This method was quick, effective and reliable, allowing a large drug volume to be administrated successfully without relying on prolonged restraint or general anesthesia of the sow. Research confirmed that Yohimbine is an effective anesthetic reversal agent in mature sows when anesthetized with xylazine, ketamine, and telazol. Yohimbine reduced overall recovery time and maintained physiological parameters closer to normal homeostatic ranges. Lastly, the results of a study assessing behavioral modification in an individual sow demonstrating oral and locomotor stereotypies suggests the promise of environmental enrichment as an effective treatment strategy for mitigating stereotypies performed in a laboratory setting.
520 $a The second objective of this dissertation was to use an optimal dosing regimen for two non-steroidal anti-inflammatory drugs (flunixin meglumine and meloxicam) to determine their efficacy in pain management using nociceptive threshold tests when lameness was induced through the use of a chemical synovitis model. Results from this study indicate that flunixin meglumine and meloxicam administration mitigated pain sensitivity in lame sows post lameness induction when pain sensitivity was evaluated with pressure algometry and thermal sensitivity tests. These analgesic drugs may be a key tool to manage pain associated with lameness.
590 $a School code: 0097.
650 4 $a Agriculture, Animal Culture and Nutrition. $3 1017857
690 $a 0475
710 2 $a Iowa State University. $b Animal Science. $3 1035695
773 0 $t Dissertation Abstracts International $g 75-10B(E).
790 $a 0097
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3627443