東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

The effect of short-term soy isoflav...

Rubin, Jessica D.

Linked to FindBook

Google Book

Amazon

博客來

The effect of short-term soy isoflavone supplementation on mRNA in localized prostate cancer.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The effect of short-term soy isoflavone supplementation on mRNA in localized prostate cancer./
Author:	Rubin, Jessica D.
Description:	127 p.
Notes:	Source: Masters Abstracts International, Volume: 52-03.
Contained By:	Masters Abstracts International52-03(E).
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1546882
ISBN:	9781303472671

The effect of short-term soy isoflavone supplementation on mRNA in localized prostate cancer.
Rubin, Jessica D.

The effect of short-term soy isoflavone supplementation on mRNA in localized prostate cancer. - 127 p.

Source: Masters Abstracts International, Volume: 52-03.

Thesis (M.S.)--University of Kansas, 2013.

Background: Soy isoflavones have been hypothesized to affect gene expression related to prostate cancer development and progression, yet few studies have evaluated the effect of this phytochemical on the transcriptome of prostate cancer cells in a human model.

ISBN: 9781303472671Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

The effect of short-term soy isoflavone supplementation on mRNA in localized prostate cancer.
LDR:03290nmm a2200301 4500 001 2055136
005 20141112080354.5
008 170521s2013 ||||||||||||||||| ||eng d
020 $a 9781303472671
035 $a (MiAaPQ)AAI1546882
035 $a AAI1546882
040 $a MiAaPQ $c MiAaPQ
100 1 $a Rubin, Jessica D. $3 3168754
245 1 4 $a The effect of short-term soy isoflavone supplementation on mRNA in localized prostate cancer.
300 $a 127 p.
500 $a Source: Masters Abstracts International, Volume: 52-03.
500 $a Adviser: Jill Hamilton-Reeves.
502 $a Thesis (M.S.)--University of Kansas, 2013.
520 $a Background: Soy isoflavones have been hypothesized to affect gene expression related to prostate cancer development and progression, yet few studies have evaluated the effect of this phytochemical on the transcriptome of prostate cancer cells in a human model.
520 $a Objective: To determine if short-term soy isoflavone supplementation influences gene expression in men with localized prostate cancer. Methods: Six men diagnosed with clinically localized prostate cancer were asked to take a soy isoflavone supplement for up to 6 weeks prior to radical prostatectomy. Total RNA was isolated and sequenced from tumor and adjacent normal frozen prostate tissue pairs obtained from these participants. Gene expression profiles were determined, differentially expressed genes were identified, and gene expression profiles were mapped to molecular pathways for biological interpretation using Ingenuity Pathway Analysis software. The trimmed mean of the M values method (TMM, where M=log2 fold change) was used to calculate the normalization factor. Quantile-adjusted conditional maximum likelihood (qCML) method was used to estimate common dispersion across all genes. Exact test with a negative binomial distribution was used to calculate expression differences between groups. Multiple test adjustments were carried out using the false discovery rate (FDR) using Benjamini and Hochberg's method. An FDR value of <0.05 was considered statistically significant.
520 $a Results: All 6 men were included in the final analysis. Soy isoflavones differentially expressed 128 genes in cancerous prostate tissue and 166 genes in normal prostate tissue. Twenty genes were differentially expressed in both tissues, 2 of which were differentially regulated by soy in different tissues. Some pathways suggested a protective effect (human embryonic stem cell pluripotency, complement system, protein citrullination, and methylglyoxal degardation VI pathways), while others suggested harm (intrinsic and extrinsic prothrombin activation and IL-17A pathways). The following pathways were of unknown relevance: acute phase response signaling, UDP-glucuronosyltransferase, and glutamate-dependent acid resistance pathways.
520 $a Conclusion: Short-term soy isoflavone supplementation prior to curative treatment for localized prostate cancer was found to significantly affect gene expression in tumor and adjacent normal prostate tissues.
590 $a School code: 0099.
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0570
710 2 $a University of Kansas. $b Dietetics and Nutrition. $3 3168755
773 0 $t Masters Abstracts International $g 52-03(E).
790 $a 0099
791 $a M.S.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1546882