Bacteriophage applications = histori...
Nicastro, Jessica.

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  • Bacteriophage applications = historical perspective and future potential /
  • Record Type: Electronic resources : Monograph/item
    Title/Author: Bacteriophage applications/ by Jessica Nicastro ... [et al.].
    Reminder of title: historical perspective and future potential /
    other author: Nicastro, Jessica.
    Published: Cham :Springer International Publishing : : 2016.,
    Description: vii, 82 p. :ill., digital ;24 cm.
    [NT 15003449]: 1. Introduction: What are Bacteriophage: a. Discovery and early phage work (including work with bacterial genetics, phage display, and phage therapy) -- b. Bacteriophage pathogenesis and host range -- c. Bacteriophage growth dynamics -- d. Bacteriophage pharmacokinetics( including mammalian host tolerance ) -- 2. Applications with Bacteriophage: a. Phage Therapy -- i. Past – why phage therapy was unsuccessful in the past and what can (and is currently) being done to improve the system -- ii. Present /Future – current research objectives and future considerations -- Host range and how it can be expanded -- Lethal agent delivery systems (bacteriocidial) -- Lethality without lysis -- b. Phage Vaccines and Phage Immunostimulation -- i. Mammalian immune response to phage -- ii. Phage vaccine delivery vehicles -- iii. Phage Immunotherapy -- c. Phage as Delivery Vehicles: i. Phage for gene delivery -- Phage display for specific cell targeting -- Considerations for use and benefits in comparison to current systems -- ii. Phage as Drug Carriers -- Selectivity and cell attachment -- Phage T2 as a potential cancer therapeutic -- Phage for delivery to the brain and CNS (including current work with Alzheimer's and drug addictions ) -- d. Phage for Bacterial Detection: i. History of Phage bacterial detection -- ii. Methods (replication assays, conjugation with bioluminescence, labelling etc. ) -- iii. Potential uses in healthcare and industry -- e. Phage for the targeting of Biofilms -- i. Phage candidates and important bacterial targets -- ii. History and potential uses in healthcare and industry -- f. Phage device coatings: i. Current phage coating practices and research -- ii. Callenges (notably phage orientation) -- iii. methods to overcome these challenges.
    Contained By: Springer eBooks
    Subject: Bacteriophages. -
    Online resource: http://dx.doi.org/10.1007/978-3-319-45791-8
    ISBN: 9783319457918
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