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System engineering approach to plann...

Swierniak, Andrzej.

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System engineering approach to planning anticancer therapies

Record Type:	Electronic resources : Monograph/item
Title/Author:	System engineering approach to planning anticancer therapies/ by Andrzej Swierniak ... [et al.].
other author:	Swierniak, Andrzej.
Published:	Cham :Springer International Publishing : : 2016.,
Description:	ix, 235 p. :ill. (some col.), digital ;24 cm.
[NT 15003449]:	Introduction -- Cell Cycle as an Object of Control -- Therapy Optimization in Population Dynamics Models -- Structured Models and Their Use in Modeling Anticancer Therapies -- Signaling Pathways Dynamics and Cancer Treatment -- Model Identification and Parameter Estimation -- Appendixes: Stability and Controllability of Dynamical Systems -- Pontryagin Maximum Principle and Optimal Control -- Bifurcation Analysis -- Numerical Implementation of the Runge Kutta and Gillespie Methods.
Contained By:	Springer eBooks
Subject:	Cancer - Treatment. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-28095-0
ISBN:	9783319280950

System engineering approach to planning anticancer therapies
System engineering approach to planning anticancer therapies[electronic resource] /by Andrzej Swierniak ... [et al.]. - Cham :Springer International Publishing :2016. - ix, 235 p. :ill. (some col.), digital ;24 cm.

Introduction -- Cell Cycle as an Object of Control -- Therapy Optimization in Population Dynamics Models -- Structured Models and Their Use in Modeling Anticancer Therapies -- Signaling Pathways Dynamics and Cancer Treatment -- Model Identification and Parameter Estimation -- Appendixes: Stability and Controllability of Dynamical Systems -- Pontryagin Maximum Principle and Optimal Control -- Bifurcation Analysis -- Numerical Implementation of the Runge Kutta and Gillespie Methods.

This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors' extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.

ISBN: 9783319280950

Standard No.: 10.1007/978-3-319-28095-0doiSubjects--Topical Terms:

618125
Cancer
--Treatment.

LC Class. No.: RC270.8

Dewey Class. No.: 616.99406

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245 0 0 $a System engineering approach to planning anticancer therapies $h [electronic resource] / $c by Andrzej Swierniak ... [et al.].
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2016.
300 $a ix, 235 p. : $b ill. (some col.), digital ; $c 24 cm.
505 0 $a Introduction -- Cell Cycle as an Object of Control -- Therapy Optimization in Population Dynamics Models -- Structured Models and Their Use in Modeling Anticancer Therapies -- Signaling Pathways Dynamics and Cancer Treatment -- Model Identification and Parameter Estimation -- Appendixes: Stability and Controllability of Dynamical Systems -- Pontryagin Maximum Principle and Optimal Control -- Bifurcation Analysis -- Numerical Implementation of the Runge Kutta and Gillespie Methods.
520 $a This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors' extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.
650 0 $a Cancer $x Treatment. $3 618125
650 0 $a Systems biology. $3 905904
650 1 4 $a Mathematics. $3 515831
650 2 4 $a Mathematical and Computational Biology. $3 1566274
650 2 4 $a Systems Theory, Control. $3 893834
650 2 4 $a Cancer Research. $3 891172
650 2 4 $a Cell Cycle Analysis. $3 1569508
650 2 4 $a Drug Resistance. $3 836316
700 1 $a Swierniak, Andrzej. $3 2195349
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-28095-0
950 $a Mathematics and Statistics (Springer-11649)