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The neuropathology of Huntington's d...

Rub, Udo.

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The neuropathology of Huntington's disease = classical findings, recent developments and correlation to functional neuroanatomy /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The neuropathology of Huntington's disease/ by Udo Rub ... [et al.].
Reminder of title:	classical findings, recent developments and correlation to functional neuroanatomy /
other author:	Rub, Udo.
Published:	Cham :Springer International Publishing : : 2015.,
Description:	xiv, 146 p. :ill., digital ;24 cm.
[NT 15003449]:	1. Introduction -- 2. The neuropathological grading of Huntington disease -- 3. The cerebral cortex in Huntington's disease -- 4. Degeneration of select motor and limbic nuclei of the thalamus in Huntington's disease -- 5. Consistent and widespread degeneration of the cerebellum in Huntington's disease -- 6. Elucidation of the role of the premotor oculomotor brainstem nuclei in the pathogenesis of oculomotor dysfunctions in Huntington's disease -- 7. Widespread brainstem neurodegeneration in Huntington's disease -- 8. Intraneuronal transport and defense mechanisms with possible pathogenetic relevance in Huntington's disease -- 9. The disease protein huntingtin and neuronal protein aggregations in Huntington's disease -- 10. Pathological nerve cell alterations in Huntington's disease (HD) and their possible role for the demise of nerve cells -- 11. Conclusions and outlook.
Contained By:	Springer eBooks
Subject:	Huntington’s disease. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-19285-7
ISBN:	9783319192857

The neuropathology of Huntington's disease = classical findings, recent developments and correlation to functional neuroanatomy /
The neuropathology of Huntington's diseaseclassical findings, recent developments and correlation to functional neuroanatomy /[electronic resource] :by Udo Rub ... [et al.]. - Cham :Springer International Publishing :2015. - xiv, 146 p. :ill., digital ;24 cm. - Advances in anatomy, embryology and cell biology,2170301-5556 ;. - Advances in anatomy, embryology and cell biology ;211..

1. Introduction -- 2. The neuropathological grading of Huntington disease -- 3. The cerebral cortex in Huntington's disease -- 4. Degeneration of select motor and limbic nuclei of the thalamus in Huntington's disease -- 5. Consistent and widespread degeneration of the cerebellum in Huntington's disease -- 6. Elucidation of the role of the premotor oculomotor brainstem nuclei in the pathogenesis of oculomotor dysfunctions in Huntington's disease -- 7. Widespread brainstem neurodegeneration in Huntington's disease -- 8. Intraneuronal transport and defense mechanisms with possible pathogenetic relevance in Huntington's disease -- 9. The disease protein huntingtin and neuronal protein aggregations in Huntington's disease -- 10. Pathological nerve cell alterations in Huntington's disease (HD) and their possible role for the demise of nerve cells -- 11. Conclusions and outlook.

This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.

ISBN: 9783319192857

Standard No.: 10.1007/978-3-319-19285-7doiSubjects--Topical Terms:

2162104
Huntington’s disease.

LC Class. No.: RC394.H85

Dewey Class. No.: 616.851

The neuropathology of Huntington's disease = classical findings, recent developments and correlation to functional neuroanatomy /
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245 0 4 $a The neuropathology of Huntington's disease $h [electronic resource] : $b classical findings, recent developments and correlation to functional neuroanatomy / $c by Udo Rub ... [et al.].
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2015.
300 $a xiv, 146 p. : $b ill., digital ; $c 24 cm.
490 1 $a Advances in anatomy, embryology and cell biology, $x 0301-5556 ; $v 217
505 0 $a 1. Introduction -- 2. The neuropathological grading of Huntington disease -- 3. The cerebral cortex in Huntington's disease -- 4. Degeneration of select motor and limbic nuclei of the thalamus in Huntington's disease -- 5. Consistent and widespread degeneration of the cerebellum in Huntington's disease -- 6. Elucidation of the role of the premotor oculomotor brainstem nuclei in the pathogenesis of oculomotor dysfunctions in Huntington's disease -- 7. Widespread brainstem neurodegeneration in Huntington's disease -- 8. Intraneuronal transport and defense mechanisms with possible pathogenetic relevance in Huntington's disease -- 9. The disease protein huntingtin and neuronal protein aggregations in Huntington's disease -- 10. Pathological nerve cell alterations in Huntington's disease (HD) and their possible role for the demise of nerve cells -- 11. Conclusions and outlook.
520 $a This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
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