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Pan-cancer integrative molecular por...

Le Tourneau, Christophe.

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Pan-cancer integrative molecular portrait towards a new paradigm in precision medicine

Record Type:	Electronic resources : Monograph/item
Title/Author:	Pan-cancer integrative molecular portrait towards a new paradigm in precision medicine/ edited by Christophe Le Tourneau, Maud Kamal.
other author:	Le Tourneau, Christophe.
Published:	Cham :Springer International Publishing : : 2015.,
Description:	x, 144 p. :ill. (some col.), digital ;24 cm.
[NT 15003449]:	Introduction: Rationale for Precision Medicine Clinical Trials -- The Key Role of Pathology in the Context of Precision Medicine Trials -- Basis for Molecular Genetics in Cancer -- Microarrays Based Molecular Profiling to Identify Genomic Alterations -- High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential -- Bioinformatics for Precision Medicine in Oncology -- Assessment of Biomarkers' Predictive Value of Efficacy -- Designs for Evaluating Precision Medicine Trials -- Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials.
Contained By:	Springer eBooks
Subject:	Clinical trials. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-22189-2
ISBN:	9783319221892

Pan-cancer integrative molecular portrait towards a new paradigm in precision medicine
Pan-cancer integrative molecular portrait towards a new paradigm in precision medicine[electronic resource] /edited by Christophe Le Tourneau, Maud Kamal. - Cham :Springer International Publishing :2015. - x, 144 p. :ill. (some col.), digital ;24 cm.

Introduction: Rationale for Precision Medicine Clinical Trials -- The Key Role of Pathology in the Context of Precision Medicine Trials -- Basis for Molecular Genetics in Cancer -- Microarrays Based Molecular Profiling to Identify Genomic Alterations -- High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential -- Bioinformatics for Precision Medicine in Oncology -- Assessment of Biomarkers' Predictive Value of Efficacy -- Designs for Evaluating Precision Medicine Trials -- Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials.

This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by implementing them in daily practice. It also covers the key role of pathology in the validation of molecular results and the complex assessment of predictive biomarkers. The different topics covered are supplemented by unique concrete examples based on the SHIVA trial. The authors are all members of the French Curie Institute, one of the world's foremost cancer research institutions.

ISBN: 9783319221892

Standard No.: 10.1007/978-3-319-22189-2doiSubjects--Topical Terms:

724498
Clinical trials.

LC Class. No.: R853.C55

Dewey Class. No.: 616.027

Pan-cancer integrative molecular portrait towards a new paradigm in precision medicine
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245 0 0 $a Pan-cancer integrative molecular portrait towards a new paradigm in precision medicine $h [electronic resource] / $c edited by Christophe Le Tourneau, Maud Kamal.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2015.
300 $a x, 144 p. : $b ill. (some col.), digital ; $c 24 cm.
505 0 $a Introduction: Rationale for Precision Medicine Clinical Trials -- The Key Role of Pathology in the Context of Precision Medicine Trials -- Basis for Molecular Genetics in Cancer -- Microarrays Based Molecular Profiling to Identify Genomic Alterations -- High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential -- Bioinformatics for Precision Medicine in Oncology -- Assessment of Biomarkers' Predictive Value of Efficacy -- Designs for Evaluating Precision Medicine Trials -- Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials.
520 $a This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by implementing them in daily practice. It also covers the key role of pathology in the validation of molecular results and the complex assessment of predictive biomarkers. The different topics covered are supplemented by unique concrete examples based on the SHIVA trial. The authors are all members of the French Curie Institute, one of the world's foremost cancer research institutions.
650 0 $a Clinical trials. $3 724498
650 0 $a Cancer $x Molecular aspects. $3 661419
650 0 $a Cancer $x Genetic aspects. $3 669248
650 1 4 $a Medicine& Public Health. $3 2160413
650 2 4 $a Oncology. $3 751006
650 2 4 $a Pathology. $3 643180
650 2 4 $a Cancer Research. $3 891172
650 2 4 $a Molecular Medicine. $3 890952
700 1 $a Le Tourneau, Christophe. $3 2160411
700 1 $a Kamal, Maud. $3 2160412
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-22189-2
950 $a Medicine (Springer-11650)