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Predictive methods in percutaneous a...

Moss, Gary P.

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Predictive methods in percutaneous absorption

Record Type:	Electronic resources : Monograph/item
Title/Author:	Predictive methods in percutaneous absorption/ by Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson.
Author:	Moss, Gary P.
other author:	Gullick, Darren R.
Published:	Berlin, Heidelberg :Springer Berlin Heidelberg : : 2015.,
Description:	xv, 199 p. :ill. (some col.), digital ;24 cm.
[NT 15003449]:	Skin Structure and Physiology -- Methods for the Measurement of Percutaneous Absorption -- Mathematical Treatments and Early Models of Skin Permeability -- "Building error upon error": The New Breadth of Research in the Field -- Algorithms for Estimating Permeability Across Artificial Membranes -- Other Approaches to Modelling Percutaneous Absorption -- "Squiggly lines and random dots - you can fit anything with a non-linear model" -- Finite-dose models of transient exposures and volatile formulation components -- "The Devil Is in the Detail …" -- Conclusions and Recommendations for Model Development and Use.
Contained By:	Springer eBooks
Subject:	Physiological, Cellular and Medical Topics. -
Online resource:	http://dx.doi.org/10.1007/978-3-662-47371-9
ISBN:	9783662473719 (electronic bk.)

Predictive methods in percutaneous absorption
Moss, Gary P.

Predictive methods in percutaneous absorption[electronic resource] /by Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson. - Berlin, Heidelberg :Springer Berlin Heidelberg :2015. - xv, 199 p. :ill. (some col.), digital ;24 cm.

Skin Structure and Physiology -- Methods for the Measurement of Percutaneous Absorption -- Mathematical Treatments and Early Models of Skin Permeability -- "Building error upon error": The New Breadth of Research in the Field -- Algorithms for Estimating Permeability Across Artificial Membranes -- Other Approaches to Modelling Percutaneous Absorption -- "Squiggly lines and random dots - you can fit anything with a non-linear model" -- Finite-dose models of transient exposures and volatile formulation components -- "The Devil Is in the Detail …" -- Conclusions and Recommendations for Model Development and Use.

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

ISBN: 9783662473719 (electronic bk.)

Standard No.: 10.1007/978-3-662-47371-9doiSubjects--Topical Terms:

891099
Physiological, Cellular and Medical Topics.

LC Class. No.: QP88.5

Dewey Class. No.: 612.79015118

Predictive methods in percutaneous absorption
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020 $a 9783662473702 (paper)
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100 1 $a Moss, Gary P. $3 2157555
245 1 0 $a Predictive methods in percutaneous absorption $h [electronic resource] / $c by Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson.
260 $a Berlin, Heidelberg : $b Springer Berlin Heidelberg : $b Imprint: Springer, $c 2015.
300 $a xv, 199 p. : $b ill. (some col.), digital ; $c 24 cm.
505 0 $a Skin Structure and Physiology -- Methods for the Measurement of Percutaneous Absorption -- Mathematical Treatments and Early Models of Skin Permeability -- "Building error upon error": The New Breadth of Research in the Field -- Algorithms for Estimating Permeability Across Artificial Membranes -- Other Approaches to Modelling Percutaneous Absorption -- "Squiggly lines and random dots - you can fit anything with a non-linear model" -- Finite-dose models of transient exposures and volatile formulation components -- "The Devil Is in the Detail …" -- Conclusions and Recommendations for Model Development and Use.
520 $a This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
650 2 4 $a Physiological, Cellular and Medical Topics. $3 891099
650 0 $a Skin absorption $x Mathematical models. $3 2157558
650 0 $a Skin absorption $x Computer simulation. $3 2157559
650 1 4 $a Biomedicine. $3 890831
650 2 4 $a Pharmacology/Toxicology. $3 890953
650 2 4 $a Human Physiology. $3 894102
650 2 4 $a Dermatology. $3 829009
700 1 $a Gullick, Darren R. $3 2157556
700 1 $a Wilkinson, Simon C. $3 2157557
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-662-47371-9
950 $a Biomedical and Life Sciences (Springer-11642)