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Kinetics of enzyme-modifier interact...

Baici, Antonio.

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Kinetics of enzyme-modifier interactions = selected topics in the theory and diagnosis of inhibition and activation mechanisms /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Kinetics of enzyme-modifier interactions/ by Antonio Baici.
Reminder of title:	selected topics in the theory and diagnosis of inhibition and activation mechanisms /
Author:	Baici, Antonio.
Published:	Vienna :Springer Vienna : : 2015.,
Description:	xvii, 489 p. :ill., digital ;24 cm.
[NT 15003449]:	Basic Knowledge -- The General Modifier Mechanism -- Taxonomy of Enzyme-Modifier Interactions and the Specific Velocity Plot -- Complements to Enzyme-Modifier Interactions -- The Basic Mechanisms of Inhibition and Nonessential Activation -- Multiple Enzyme-Modifier Interactions -- Multiple Interactions: Essential Activation and Liberation -- Slow-Onset Enzyme Inhibition -- Enzyme Inactivation with a Note on the Significance of Slow Modification Processes -- Dichotomous Keys to Enzyme-Modification Mechanisms. .
Contained By:	Springer eBooks
Subject:	Enzyme inhibitors. -
Online resource:	http://dx.doi.org/10.1007/978-3-7091-1402-5
ISBN:	9783709114025 (electronic bk.)

Kinetics of enzyme-modifier interactions = selected topics in the theory and diagnosis of inhibition and activation mechanisms /
Baici, Antonio.

Kinetics of enzyme-modifier interactionsselected topics in the theory and diagnosis of inhibition and activation mechanisms /[electronic resource] :by Antonio Baici. - Vienna :Springer Vienna :2015. - xvii, 489 p. :ill., digital ;24 cm.

Basic Knowledge -- The General Modifier Mechanism -- Taxonomy of Enzyme-Modifier Interactions and the Specific Velocity Plot -- Complements to Enzyme-Modifier Interactions -- The Basic Mechanisms of Inhibition and Nonessential Activation -- Multiple Enzyme-Modifier Interactions -- Multiple Interactions: Essential Activation and Liberation -- Slow-Onset Enzyme Inhibition -- Enzyme Inactivation with a Note on the Significance of Slow Modification Processes -- Dichotomous Keys to Enzyme-Modification Mechanisms. .

The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.

ISBN: 9783709114025 (electronic bk.)

Standard No.: 10.1007/978-3-7091-1402-5doiSubjects--Topical Terms:

915932
Enzyme inhibitors.

LC Class. No.: QP601.4

Dewey Class. No.: 572.7

Kinetics of enzyme-modifier interactions = selected topics in the theory and diagnosis of inhibition and activation mechanisms /
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245 1 0 $a Kinetics of enzyme-modifier interactions $h [electronic resource] : $b selected topics in the theory and diagnosis of inhibition and activation mechanisms / $c by Antonio Baici.
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505 0 $a Basic Knowledge -- The General Modifier Mechanism -- Taxonomy of Enzyme-Modifier Interactions and the Specific Velocity Plot -- Complements to Enzyme-Modifier Interactions -- The Basic Mechanisms of Inhibition and Nonessential Activation -- Multiple Enzyme-Modifier Interactions -- Multiple Interactions: Essential Activation and Liberation -- Slow-Onset Enzyme Inhibition -- Enzyme Inactivation with a Note on the Significance of Slow Modification Processes -- Dichotomous Keys to Enzyme-Modification Mechanisms. .
520 $a The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.
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650 0 $a Enzyme activation. $3 659204
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650 2 4 $a Protein-Ligand Interactions. $3 1006101
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650 2 4 $a Biophysics and Biological Physics. $3 1066311
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