東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Hyperbranched polydendrons = a new m...

Hatton, Fiona L.

Linked to FindBook

Google Book

Amazon

博客來

Hyperbranched polydendrons = a new macromolecular architecture /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Hyperbranched polydendrons/ by Fiona L. Hatton.
Reminder of title:	a new macromolecular architecture /
Author:	Hatton, Fiona L.
Published:	Cham :Springer International Publishing : : 2015.,
Description:	xxii, 260 p. :ill. (some col.), digital ;24 cm.
[NT 15003449]:	Introduction -- Synthesis and characterisation of hyp-polydendron materials and subsequent anoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and aqueous nanoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and formation of sterically stabilised nanoparticles -- Hyp-Polydendrons; studies of nanoprecipitation behavior -- Conclusions and Future work -- Experimental.
Contained By:	Springer eBooks
Subject:	Branched polymers. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-18753-2
ISBN:	9783319187532 (electronic bk.)

Hyperbranched polydendrons = a new macromolecular architecture /
Hatton, Fiona L.

Hyperbranched polydendronsa new macromolecular architecture /[electronic resource] :by Fiona L. Hatton. - Cham :Springer International Publishing :2015. - xxii, 260 p. :ill. (some col.), digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Synthesis and characterisation of hyp-polydendron materials and subsequent anoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and aqueous nanoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and formation of sterically stabilised nanoparticles -- Hyp-Polydendrons; studies of nanoprecipitation behavior -- Conclusions and Future work -- Experimental.

This thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles – a research goal that is currently being pursued by several groups around the globe.

ISBN: 9783319187532 (electronic bk.)

Standard No.: 10.1007/978-3-319-18753-2doiSubjects--Topical Terms:

2153089
Branched polymers.

LC Class. No.: QD382.B73

Dewey Class. No.: 547.7

Hyperbranched polydendrons = a new macromolecular architecture /
LDR:02598nmm a2200325 a 4500 001 2006240
003 DE-He213
005 20151211110515.0
006 m d
007 cr nn 008maaau
008 160114s2015 gw s 0 eng d
020 $a 9783319187532 (electronic bk.)
020 $a 9783319187525 (paper)
024 7 $a 10.1007/978-3-319-18753-2 $2 doi
035 $a 978-3-319-18753-2
040 $a GP $c GP
041 0 $a eng
050 4 $a QD382.B73
072 7 $a PSB $2 bicssc
072 7 $a SCI013020 $2 bisacsh
082 0 4 $a 547.7 $2 23
090 $a QD382.B73 $b H366 2015
100 1 $a Hatton, Fiona L. $3 2153088
245 1 0 $a Hyperbranched polydendrons $h [electronic resource] : $b a new macromolecular architecture / $c by Fiona L. Hatton.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2015.
300 $a xxii, 260 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5053
505 0 $a Introduction -- Synthesis and characterisation of hyp-polydendron materials and subsequent anoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and aqueous nanoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and formation of sterically stabilised nanoparticles -- Hyp-Polydendrons; studies of nanoprecipitation behavior -- Conclusions and Future work -- Experimental.
520 $a This thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles – a research goal that is currently being pursued by several groups around the globe.
650 0 $a Branched polymers. $3 2153089
650 0 $a Dendrimers. $3 735112
650 1 4 $a Chemistry. $3 516420
650 2 4 $a Medicinal Chemistry. $3 892420
650 2 4 $a Polymer Sciences. $3 890859
650 2 4 $a Nanochemistry. $3 813421
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
830 0 $a Springer theses. $3 1314442
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-18753-2
950 $a Chemistry and Materials Science (Springer-11644)