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The Casein Kinase 1 Epsilon Gene: F...

Goulet, Gillian.

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The Casein Kinase 1 Epsilon Gene: Food and Drug Response to a Psychomotor Stimulant.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The Casein Kinase 1 Epsilon Gene: Food and Drug Response to a Psychomotor Stimulant./
Author:	Goulet, Gillian.
Description:	119 p.
Notes:	Source: Masters Abstracts International, Volume: 52-05.
Contained By:	Masters Abstracts International52-05(E).
Subject:	Health Sciences, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MS00028
ISBN:	9780499000286

The Casein Kinase 1 Epsilon Gene: Food and Drug Response to a Psychomotor Stimulant.
Goulet, Gillian.

The Casein Kinase 1 Epsilon Gene: Food and Drug Response to a Psychomotor Stimulant. - 119 p.

Source: Masters Abstracts International, Volume: 52-05.

Thesis (M.Sc.)--York University (Canada), 2013.

Palatable foods in our environment activate the reward centres in our brain and tend to foster eating beyond caloric needs. Psychomotor stimulant drugs also regulate the reward pathway via dopamine (DA) release, typically causing appetite suppression. However, research shows that this response varies across individuals. ADHD is a disorder characterized by inattentiveness and distractibility, and is associated with low DA levels in the brain. Therapeutic treatment with methylphenidate (MP) increases DA levels to improve attention, but again, response varies. This study investigated whether genetic variation of three single nucleotide polymorphisms of the Casein Kinase 1 Epsilon Gene (Csnk1e) - a gene that regulates a protein found to affect drug sensitivity - results in changes in mood and eating variables in response to the stimulant drug, MP. By employing a drug vs. placebo, double-blind, cross-over design with 134 healthy adults, results indicated that individuals with C/C and C/G genotypes of the rs135745 SNP showed significant decreases in appetite ratings and food cravings in response to a MP induced snack-food challenge. Implications are discussed regarding proper drug treatment for ADHD to reduce side effects such as loss of appetite.

ISBN: 9780499000286Subjects--Topical Terms:

1017817
Health Sciences, General.

The Casein Kinase 1 Epsilon Gene: Food and Drug Response to a Psychomotor Stimulant.
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100 1 $a Goulet, Gillian. $3 2106340
245 1 4 $a The Casein Kinase 1 Epsilon Gene: Food and Drug Response to a Psychomotor Stimulant.
300 $a 119 p.
500 $a Source: Masters Abstracts International, Volume: 52-05.
502 $a Thesis (M.Sc.)--York University (Canada), 2013.
520 $a Palatable foods in our environment activate the reward centres in our brain and tend to foster eating beyond caloric needs. Psychomotor stimulant drugs also regulate the reward pathway via dopamine (DA) release, typically causing appetite suppression. However, research shows that this response varies across individuals. ADHD is a disorder characterized by inattentiveness and distractibility, and is associated with low DA levels in the brain. Therapeutic treatment with methylphenidate (MP) increases DA levels to improve attention, but again, response varies. This study investigated whether genetic variation of three single nucleotide polymorphisms of the Casein Kinase 1 Epsilon Gene (Csnk1e) - a gene that regulates a protein found to affect drug sensitivity - results in changes in mood and eating variables in response to the stimulant drug, MP. By employing a drug vs. placebo, double-blind, cross-over design with 134 healthy adults, results indicated that individuals with C/C and C/G genotypes of the rs135745 SNP showed significant decreases in appetite ratings and food cravings in response to a MP induced snack-food challenge. Implications are discussed regarding proper drug treatment for ADHD to reduce side effects such as loss of appetite.
590 $a School code: 0267.
650 4 $a Health Sciences, General. $3 1017817
650 4 $a Biology, Genetics. $3 1017730
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690 $a 0369
710 2 $a York University (Canada). $3 1017889
773 0 $t Masters Abstracts International $g 52-05(E).
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791 $a M.Sc.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MS00028