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Pathophysiology of hemorrhagic shock...

Fleckenstein, Annette Elizabeth.

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Pathophysiology of hemorrhagic shock and the protective effects of antioxidants.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Pathophysiology of hemorrhagic shock and the protective effects of antioxidants./
Author:	Fleckenstein, Annette Elizabeth.
Description:	67 p.
Notes:	Source: Masters Abstracts International, Volume: 28-04, page: 5880.
Contained By:	Masters Abstracts International28-04.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1339827

Pathophysiology of hemorrhagic shock and the protective effects of antioxidants.
Fleckenstein, Annette Elizabeth.

Pathophysiology of hemorrhagic shock and the protective effects of antioxidants. - 67 p.

Source: Masters Abstracts International, Volume: 28-04, page: 5880.

Thesis (M.S.)--Western Michigan University, 1990.

Considerable attention has focused on the role of free radicals in the pathophysiology of hemorrhagic shock. In this study, four pharmacological mechanisms for antagonizing free radical generation or reactions were compared in terms of their efficacy in attenuating post-hemorrhage (post-reinfusion) cardiovascular collapse. These included blocking arachidonic acid oxidation by cyclooxygenase (eg; ibuprofen), inhibiting superoxide radical production by xanthine oxidase (eg; oxypurinol), chelating iron (eg; desferal), and inhibiting lipid peroxidation (eg; U74006F and U78517G, Upjohn Company, Kalamazoo, Michigan).Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Pathophysiology of hemorrhagic shock and the protective effects of antioxidants.
LDR:01942nam a2200265 4500 001 1967925
005 20141121133040.5
008 150210s1990 ||||||||||||||||| ||eng d
035 $a (MiAaPQ)AAI1339827
035 $a AAI1339827
040 $a MiAaPQ $c MiAaPQ
100 1 $a Fleckenstein, Annette Elizabeth. $3 2105016
245 1 0 $a Pathophysiology of hemorrhagic shock and the protective effects of antioxidants.
300 $a 67 p.
500 $a Source: Masters Abstracts International, Volume: 28-04, page: 5880.
500 $a Adviser: Leonard Beuving.
502 $a Thesis (M.S.)--Western Michigan University, 1990.
520 $a Considerable attention has focused on the role of free radicals in the pathophysiology of hemorrhagic shock. In this study, four pharmacological mechanisms for antagonizing free radical generation or reactions were compared in terms of their efficacy in attenuating post-hemorrhage (post-reinfusion) cardiovascular collapse. These included blocking arachidonic acid oxidation by cyclooxygenase (eg; ibuprofen), inhibiting superoxide radical production by xanthine oxidase (eg; oxypurinol), chelating iron (eg; desferal), and inhibiting lipid peroxidation (eg; U74006F and U78517G, Upjohn Company, Kalamazoo, Michigan).
520 $a Cardiovascular function, cerebral blood flow, arterial blood gases, serum glucose, and plasma vitamin E were examined in a hemorrhage/reperfusion model using urethane-anesthetized rats. U74006F and U785l7G attenuated the progressive cardiovascular collapse characteristic of hemorrhagic shock whereas ibuprofen, desferal, and oxypurinol were ineffective. Protection against the progressive decline in cerebral blood flow associated with hemorrhagic shock was observed only in U74006F-treated rats.
590 $a School code: 0257.
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0419
710 2 $a Western Michigan University. $3 804473
773 0 $t Masters Abstracts International $g 28-04.
790 $a 0257
791 $a M.S.
792 $a 1990
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1339827