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Synthesis of new small-molecule libr...

Liu, Song.

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Synthesis of new small-molecule libraries based on natural products.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Synthesis of new small-molecule libraries based on natural products./
Author:	Liu, Song.
Description:	387 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-01(E), Section: B.
Contained By:	Dissertation Abstracts International75-01B(E).
Subject:	Chemistry, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3595941
ISBN:	9781303423161

Synthesis of new small-molecule libraries based on natural products.
Liu, Song.

Synthesis of new small-molecule libraries based on natural products. - 387 p.

Source: Dissertation Abstracts International, Volume: 75-01(E), Section: B.

Thesis (Ph.D.)--The University of Chicago, 2013.

This dissertation describes the synthesis of 3 new small-molecule libraries based on natural products. The first library is based on the Corynanthe family of alkaloid natural products, featuring a Michael addition/cyclization/Pictet-Spengler strategy. The second library is based on the biosynthesis of Mitragynine Pseudoindoxyl and Pumiloside from Strictosidine. Chemo-selective transformations of the indole moiety in the library compounds have been achieved to mimic the biosynthetic process. The third library is based on the total synthesis of 3-Deoxyrosaranolide, in which a modular and parallel synthesis of 16- to 19-membered macrolides and their derivatives has been completed.

ISBN: 9781303423161Subjects--Topical Terms:

1021807
Chemistry, General.

Synthesis of new small-molecule libraries based on natural products.
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020 $a 9781303423161
035 $a (MiAaPQ)AAI3595941
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100 1 $a Liu, Song. $3 1275819
245 1 0 $a Synthesis of new small-molecule libraries based on natural products.
300 $a 387 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-01(E), Section: B.
500 $a Adviser: Sergey A. Kozmin.
502 $a Thesis (Ph.D.)--The University of Chicago, 2013.
520 $a This dissertation describes the synthesis of 3 new small-molecule libraries based on natural products. The first library is based on the Corynanthe family of alkaloid natural products, featuring a Michael addition/cyclization/Pictet-Spengler strategy. The second library is based on the biosynthesis of Mitragynine Pseudoindoxyl and Pumiloside from Strictosidine. Chemo-selective transformations of the indole moiety in the library compounds have been achieved to mimic the biosynthetic process. The third library is based on the total synthesis of 3-Deoxyrosaranolide, in which a modular and parallel synthesis of 16- to 19-membered macrolides and their derivatives has been completed.
590 $a School code: 0330.
650 4 $a Chemistry, General. $3 1021807
650 4 $a Chemistry, Organic. $3 516206
690 $a 0485
690 $a 0490
710 2 $a The University of Chicago. $b Chemistry. $3 1675066
773 0 $t Dissertation Abstracts International $g 75-01B(E).
790 $a 0330
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3595941