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Quantitative mass spectrometry analy...

Yang, Lan.

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Quantitative mass spectrometry analysis for pharmaceutical applications.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Quantitative mass spectrometry analysis for pharmaceutical applications./
Author:	Yang, Lan.
Description:	256 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-05(E), Section: B.
Contained By:	Dissertation Abstracts International75-05B(E).
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3608526
ISBN:	9781303666889

Quantitative mass spectrometry analysis for pharmaceutical applications.
Yang, Lan.

Quantitative mass spectrometry analysis for pharmaceutical applications. - 256 p.

Source: Dissertation Abstracts International, Volume: 75-05(E), Section: B.

Thesis (Ph.D.)--University of Massachusetts Boston, 2013.

In 2008, United States Pharmacopeial Convention (USP) proposed a new general chapter to replace the outdated and qualitative heavy metal test specified in USP Heavy Metals . In 2010, USP proposed two new general chapters, Elemental Impurities Limits and Procedures , specifying sixteen elements that need to be controlled in drug articles. Chapter 1 of this dissertation focuses on an ICP-MS method developed and qualified as a replacement method for the quantification of these sixteen elements. To minimize sample matrix effects, a one-point standard addition method was applied for the quantification of fifteen elements. Due to the toxicity of osmium, a semi-quantitative analysis was applied using nine non-Os standards. This method was qualified for specificity, sensitivity, accuracy, precision and linearity with satisfactory results for the release test for a soluble drug substance.

ISBN: 9781303666889Subjects--Topical Terms:

586156
Chemistry, Analytical.

Quantitative mass spectrometry analysis for pharmaceutical applications.
LDR:03254nam a2200301 4500 001 1967658
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008 150210s2013 ||||||||||||||||| ||eng d
020 $a 9781303666889
035 $a (MiAaPQ)AAI3608526
035 $a AAI3608526
040 $a MiAaPQ $c MiAaPQ
100 1 $a Yang, Lan. $3 729229
245 1 0 $a Quantitative mass spectrometry analysis for pharmaceutical applications.
300 $a 256 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-05(E), Section: B.
500 $a Advisers: Jason Evans; Donghui Wang.
502 $a Thesis (Ph.D.)--University of Massachusetts Boston, 2013.
520 $a In 2008, United States Pharmacopeial Convention (USP) proposed a new general chapter to replace the outdated and qualitative heavy metal test specified in USP Heavy Metals . In 2010, USP proposed two new general chapters, Elemental Impurities Limits and Procedures , specifying sixteen elements that need to be controlled in drug articles. Chapter 1 of this dissertation focuses on an ICP-MS method developed and qualified as a replacement method for the quantification of these sixteen elements. To minimize sample matrix effects, a one-point standard addition method was applied for the quantification of fifteen elements. Due to the toxicity of osmium, a semi-quantitative analysis was applied using nine non-Os standards. This method was qualified for specificity, sensitivity, accuracy, precision and linearity with satisfactory results for the release test for a soluble drug substance.
520 $a Chapter 2 of this dissertation focuses on the development of an in vitro lipase activity assay using LC-MS to quantify oleic acid. Compared to the USP pH titration assay, this method has no pH limitation with native triolein substrate. Cross-linked lipase crystal (CLLC) was bioengineered to protect its activity in the acidic environment of the stomach, while maintaining its activity in the small intestine through differences in solubility. Solubility-activity relationship is the most important attribute of CLLC, which is designed to improve its in vivo efficacy. Two CLLCs were characterized with various analytical techniques and this LC-MS method. In vivo test demonstrated that CLLC more efficiently improved patient fat digestion compared to its porcine derived lipase counterpart.
520 $a Chapter 3 summarizes preliminary results for the synthesis and characterization of a Phos-Tag linker that could potentially be used to quantify phoshphorylated peptides and proteins. Phos-Tag is an organic macro-molecule with Zn metal centers, which bind to phosphate group through electron donation from two oxygen atoms. Phos-Tag binding to different phospho-amino acids was examined with ESI-MS. The preliminary results demonstrated Phos-Tag has strong binding affinity to phospho-amino acids, which could be used for absolute quantification of phosphopeptide or phosphoprotein with ICP-MS or laser ablation ICP-MS tissue imaging analysis.
590 $a School code: 1074.
650 4 $a Chemistry, Analytical. $3 586156
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0486
690 $a 0572
710 2 $a University of Massachusetts Boston. $b Chemistry/Physical/Analytical Chemistry (PhD). $3 2104709
773 0 $t Dissertation Abstracts International $g 75-05B(E).
790 $a 1074
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3608526