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Application of DNA arrays and develo...

Yuan, Yuan.

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Application of DNA arrays and development of sequence-specific capture of DNA/protein complexes.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Application of DNA arrays and development of sequence-specific capture of DNA/protein complexes./
Author:	Yuan, Yuan.
Description:	103 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-04(E), Section: B.
Contained By:	Dissertation Abstracts International75-04B(E).
Subject:	Chemistry, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3607266
ISBN:	9781303647956

Application of DNA arrays and development of sequence-specific capture of DNA/protein complexes.
Yuan, Yuan.

Application of DNA arrays and development of sequence-specific capture of DNA/protein complexes. - 103 p.

Source: Dissertation Abstracts International, Volume: 75-04(E), Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2014.

Methodology development to identify proteins that interact with the genome at specific locations is critical as it is widely recognized that much of gene regulation is controlled by gene-specific protein-DNA interactions. Recent developments on high density DNA arrays and powerful high-throughput mass spectrometry platforms have made it possible to query biological systems at the genome and proteome levels. There are three parts to this dissertation 1) we integrate DNA arrays with microfluidic aptamer selection and next generation DNA sequencing for rapid and efficient aptamer characterization and screening; 2) we investigate sequence-specific DNA-protein interactions in vitro; 3) we develop new protocols to investigate sequence-specific DNA-protein interactions in vivo..

ISBN: 9781303647956Subjects--Topical Terms:

1021807
Chemistry, General.

Application of DNA arrays and development of sequence-specific capture of DNA/protein complexes.
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245 1 0 $a Application of DNA arrays and development of sequence-specific capture of DNA/protein complexes.
300 $a 103 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-04(E), Section: B.
500 $a Adviser: Lloyd M. Smith.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2014.
520 $a Methodology development to identify proteins that interact with the genome at specific locations is critical as it is widely recognized that much of gene regulation is controlled by gene-specific protein-DNA interactions. Recent developments on high density DNA arrays and powerful high-throughput mass spectrometry platforms have made it possible to query biological systems at the genome and proteome levels. There are three parts to this dissertation 1) we integrate DNA arrays with microfluidic aptamer selection and next generation DNA sequencing for rapid and efficient aptamer characterization and screening; 2) we investigate sequence-specific DNA-protein interactions in vitro; 3) we develop new protocols to investigate sequence-specific DNA-protein interactions in vivo..
590 $a School code: 0262.
650 4 $a Chemistry, General. $3 1021807
650 4 $a Chemistry, Analytical. $3 586156
690 $a 0485
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710 2 $a The University of Wisconsin - Madison. $b Chemistry. $3 2049906
773 0 $t Dissertation Abstracts International $g 75-04B(E).
790 $a 0262
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3607266