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Mapping Molecular Space with Mass Sp...

Nguyen, Don Duy.

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Mapping Molecular Space with Mass Spectrometry.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Mapping Molecular Space with Mass Spectrometry./
Author:	Nguyen, Don Duy.
Description:	94 p.
Notes:	Source: Masters Abstracts International, Volume: 52-02.
Contained By:	Masters Abstracts International52-02(E).
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1544018
ISBN:	9781303329401

Mapping Molecular Space with Mass Spectrometry.
Nguyen, Don Duy.

Mapping Molecular Space with Mass Spectrometry. - 94 p.

Source: Masters Abstracts International, Volume: 52-02.

Thesis (M.S.)--University of California, San Diego, 2013.

Mass spectrometry has become an invaluable tool in the discovery and characterization of specialized metabolites and biotechnologically relevant molecules. One aspect of characterizing specialized metabolites involves connecting these molecules to their biosynthetic machineries. Here we employ several mass spectrometry methods and introduce the idea of connecting molecular families to their gene cluster families on a large scale that takes advantage of publicly accessible genomes. As proof of principle, we used molecular networking to analyze sixty bacteria, 42 bacilli and 18 pseudomonads, simultaneously and matched eight molecular families to their gene cluster families. To illustrate the effectiveness of this technique, we combined it with imaging mass spectrometry to examine two marine Pseudoalteromonas that both showed inhibition against Bacillus subtilis 3610. The signals showing bioactivity against B. subtilis were shown to be a family of molecules for which the biosynthetic gene cluster was discovered using a publiclyavailable genome sequence from Pseudoalteromonas piscicida JCM 20779T.

ISBN: 9781303329401Subjects--Topical Terms:

586156
Chemistry, Analytical.

Mapping Molecular Space with Mass Spectrometry.
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008 150210s2013 ||||||||||||||||| ||eng d
020 $a 9781303329401
035 $a (MiAaPQ)AAI1544018
035 $a AAI1544018
040 $a MiAaPQ $c MiAaPQ
100 1 $a Nguyen, Don Duy. $3 2104575
245 1 0 $a Mapping Molecular Space with Mass Spectrometry.
300 $a 94 p.
500 $a Source: Masters Abstracts International, Volume: 52-02.
500 $a Adviser: Pieter C. Dorrestein.
502 $a Thesis (M.S.)--University of California, San Diego, 2013.
520 $a Mass spectrometry has become an invaluable tool in the discovery and characterization of specialized metabolites and biotechnologically relevant molecules. One aspect of characterizing specialized metabolites involves connecting these molecules to their biosynthetic machineries. Here we employ several mass spectrometry methods and introduce the idea of connecting molecular families to their gene cluster families on a large scale that takes advantage of publicly accessible genomes. As proof of principle, we used molecular networking to analyze sixty bacteria, 42 bacilli and 18 pseudomonads, simultaneously and matched eight molecular families to their gene cluster families. To illustrate the effectiveness of this technique, we combined it with imaging mass spectrometry to examine two marine Pseudoalteromonas that both showed inhibition against Bacillus subtilis 3610. The signals showing bioactivity against B. subtilis were shown to be a family of molecules for which the biosynthetic gene cluster was discovered using a publiclyavailable genome sequence from Pseudoalteromonas piscicida JCM 20779T.
590 $a School code: 0033.
650 4 $a Chemistry, Analytical. $3 586156
690 $a 0486
710 2 $a University of California, San Diego. $b Chemistry. $3 1023460
773 0 $t Masters Abstracts International $g 52-02(E).
790 $a 0033
791 $a M.S.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1544018