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Biomimetic calcium phosphate coating...

Li, Ling.

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Biomimetic calcium phosphate coatings synthesized by electrochemical deposition and air plasma spray: Morphology, composition and bioactive performance.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Biomimetic calcium phosphate coatings synthesized by electrochemical deposition and air plasma spray: Morphology, composition and bioactive performance./
Author:	Li, Ling.
Description:	147 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.
Contained By:	Dissertation Abstracts International75-02B(E).
Subject:	Engineering, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3599127
ISBN:	9781303482731

Biomimetic calcium phosphate coatings synthesized by electrochemical deposition and air plasma spray: Morphology, composition and bioactive performance.
Li, Ling.

Biomimetic calcium phosphate coatings synthesized by electrochemical deposition and air plasma spray: Morphology, composition and bioactive performance. - 147 p.

Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.

Thesis (Ph.D.)--State University of New York at Stony Brook, 2013.

In this project, with the aim to develop bioactive biomimetic coatings for dental and orthopedic applications, calcium phosphate based coatings deposited by electrochemical deposition and plasma spray were investigated. Different combinations of process parameters were used to achieve coatings with various chemical compositions and morphologies. The obtained coating composition was investigated by energy dispersive X-ray spectroscopy and X-ray diffraction. The microstructure of the coatings were studied through scanning electron microscopy while the cytocompatibility and bioactivity of the strontium-doped calcium phosphate coatings were evaluated using bone cell culture using MC3T3-E1 osteoblast-like cells. A set of designed experiments were performed to study the process-product-performance relationship. The experimental results suggested that the properties of the coatings were dramatically impacted by process parameters during both of the air plasma spray and electrochemical deposition processes. For electrochemical deposition, the influences of different process parameters such as current density, concentration, temperature and pH value of the electrolyte as well as the dose of strontium were investigated. A thermodynamic model was built to describe the calcium phosphate deposition behaviors in this process, which enhanced the understanding of this process, provided the possibility to predict and tailor the properties of deposited coatings. As for air plasma sprayed calcium phosphate coating, the links between process parameters--> particle state--> coating properties --> performance were successfully built through process map strategy. It was found that current and total gas flow were the key process parameters in this process, which controlled in-flame particle state, the morphologies of single splats, and eventually coating properties such as coating's phase, microstructure as well as coating thickness and the bioactivities of the coatings. The in-vitro cell culture experiment indicated that coating morphology and composition had dramatic impact on the behaviors of the cells: faceted monetie produced by electrodeposition was the most suitable substrate for the attachment and growth of the cells, compared to smoother air plasma sprayed calcium phosphate coatings and electrochemical deposited needle-like hydroxyapatite. Furthermore, the incorporation of strontium into calcium phosphate coatings leaded to enhanced cell proliferation suggesting its potential benefits for improving the bioactivity of the calcium phosphate coatings.

ISBN: 9781303482731Subjects--Topical Terms:

1020744
Engineering, General.

Biomimetic calcium phosphate coatings synthesized by electrochemical deposition and air plasma spray: Morphology, composition and bioactive performance.
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245 1 0 $a Biomimetic calcium phosphate coatings synthesized by electrochemical deposition and air plasma spray: Morphology, composition and bioactive performance.
300 $a 147 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.
500 $a Adviser: Christopher Weyant.
502 $a Thesis (Ph.D.)--State University of New York at Stony Brook, 2013.
520 $a In this project, with the aim to develop bioactive biomimetic coatings for dental and orthopedic applications, calcium phosphate based coatings deposited by electrochemical deposition and plasma spray were investigated. Different combinations of process parameters were used to achieve coatings with various chemical compositions and morphologies. The obtained coating composition was investigated by energy dispersive X-ray spectroscopy and X-ray diffraction. The microstructure of the coatings were studied through scanning electron microscopy while the cytocompatibility and bioactivity of the strontium-doped calcium phosphate coatings were evaluated using bone cell culture using MC3T3-E1 osteoblast-like cells. A set of designed experiments were performed to study the process-product-performance relationship. The experimental results suggested that the properties of the coatings were dramatically impacted by process parameters during both of the air plasma spray and electrochemical deposition processes. For electrochemical deposition, the influences of different process parameters such as current density, concentration, temperature and pH value of the electrolyte as well as the dose of strontium were investigated. A thermodynamic model was built to describe the calcium phosphate deposition behaviors in this process, which enhanced the understanding of this process, provided the possibility to predict and tailor the properties of deposited coatings. As for air plasma sprayed calcium phosphate coating, the links between process parameters--> particle state--> coating properties --> performance were successfully built through process map strategy. It was found that current and total gas flow were the key process parameters in this process, which controlled in-flame particle state, the morphologies of single splats, and eventually coating properties such as coating's phase, microstructure as well as coating thickness and the bioactivities of the coatings. The in-vitro cell culture experiment indicated that coating morphology and composition had dramatic impact on the behaviors of the cells: faceted monetie produced by electrodeposition was the most suitable substrate for the attachment and growth of the cells, compared to smoother air plasma sprayed calcium phosphate coatings and electrochemical deposited needle-like hydroxyapatite. Furthermore, the incorporation of strontium into calcium phosphate coatings leaded to enhanced cell proliferation suggesting its potential benefits for improving the bioactivity of the calcium phosphate coatings.
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