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Effect of Coating Titanium Implants ...

Qari, Maha Rahmatullah.

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Effect of Coating Titanium Implants with Silk on Osseointegration.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Effect of Coating Titanium Implants with Silk on Osseointegration./
Author:	Qari, Maha Rahmatullah.
Description:	34 p.
Notes:	Source: Masters Abstracts International, Volume: 52-03.
Contained By:	Masters Abstracts International52-03(E).
Subject:	Health Sciences, Dentistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1547329
ISBN:	9781303487781

Effect of Coating Titanium Implants with Silk on Osseointegration.
Qari, Maha Rahmatullah.

Effect of Coating Titanium Implants with Silk on Osseointegration. - 34 p.

Source: Masters Abstracts International, Volume: 52-03.

Thesis (M.S.)--Tufts University School of Dental Medicine, 2013.

Available in-vitro data suggest that surface modeling of inert titanium with silk enhances its interaction with the biological environment. Furthermore, incorporating arginine-glycine-aspartic acid (RGD) peptides into silk might stimulate the adhesion of fibroblasts leading to an accelerated osseointegration. The purpose of this study was to test the effect of coating implants with RGD-decorated silk on osseointegration in an in-vivo parallel design, randomized controlled trial in an animal model. A total of 18 titanium implants were used. Each animal received 3 coated (test) and 3 uncoated (control) implants placed in their tibiae. Bone samples were collected at 2, 4, and 6 weeks post-implant placement. The percentage of bone-to-implant contact (BIC) was assessed histologically. Different inflammatory cells were identified around each implant to assess the inflammatory response. The BIC in the test group was higher than the control group (82% vs. 62%, p = 0.083) at 2 weeks but lower at 4 weeks (39% vs. 57%, p = 0.275) and 6 weeks (32% vs. 34%, p=1.000), but none of these differences were statistically significant. The number of lymphocytes was higher in the test group at 2, 4, and 6 weeks (p=0.025, 0.034, and 0.025, respectively). Lymphocytes, MN Giant cells and macrophages were also higher in number with statistical significance in the test group across the different time points. Our data suggest that coating implants with RGD decorated silk does not improve the short-term BIC and initiates a higher inflammatory response. However, further studies with larger sample sizes and modified coating protocol, are needed to be performed.

ISBN: 9781303487781Subjects--Topical Terms:

1019378
Health Sciences, Dentistry.

Effect of Coating Titanium Implants with Silk on Osseointegration.
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100 1 $a Qari, Maha Rahmatullah. $3 2102365
245 1 0 $a Effect of Coating Titanium Implants with Silk on Osseointegration.
300 $a 34 p.
500 $a Source: Masters Abstracts International, Volume: 52-03.
500 $a Includes supplementary digital materials.
500 $a Adviser: Driss Zoukhri.
502 $a Thesis (M.S.)--Tufts University School of Dental Medicine, 2013.
520 $a Available in-vitro data suggest that surface modeling of inert titanium with silk enhances its interaction with the biological environment. Furthermore, incorporating arginine-glycine-aspartic acid (RGD) peptides into silk might stimulate the adhesion of fibroblasts leading to an accelerated osseointegration. The purpose of this study was to test the effect of coating implants with RGD-decorated silk on osseointegration in an in-vivo parallel design, randomized controlled trial in an animal model. A total of 18 titanium implants were used. Each animal received 3 coated (test) and 3 uncoated (control) implants placed in their tibiae. Bone samples were collected at 2, 4, and 6 weeks post-implant placement. The percentage of bone-to-implant contact (BIC) was assessed histologically. Different inflammatory cells were identified around each implant to assess the inflammatory response. The BIC in the test group was higher than the control group (82% vs. 62%, p = 0.083) at 2 weeks but lower at 4 weeks (39% vs. 57%, p = 0.275) and 6 weeks (32% vs. 34%, p=1.000), but none of these differences were statistically significant. The number of lymphocytes was higher in the test group at 2, 4, and 6 weeks (p=0.025, 0.034, and 0.025, respectively). Lymphocytes, MN Giant cells and macrophages were also higher in number with statistical significance in the test group across the different time points. Our data suggest that coating implants with RGD decorated silk does not improve the short-term BIC and initiates a higher inflammatory response. However, further studies with larger sample sizes and modified coating protocol, are needed to be performed.
590 $a School code: 1547.
650 4 $a Health Sciences, Dentistry. $3 1019378
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0567
690 $a 0541
710 2 $a Tufts University School of Dental Medicine. $b Periodontology. $3 2102366
773 0 $t Masters Abstracts International $g 52-03(E).
790 $a 1547
791 $a M.S.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1547329