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Pharmacological modulation of muscle...

Awadalla, Nancy Amin.

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Pharmacological modulation of muscle-derived stem cells for the repair of ischemic and/or necrotic skeletal muscle.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Pharmacological modulation of muscle-derived stem cells for the repair of ischemic and/or necrotic skeletal muscle./
Author:	Awadalla, Nancy Amin.
Description:	69 p.
Notes:	Source: Masters Abstracts International, Volume: 52-01.
Contained By:	Masters Abstracts International52-01(E).
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1523469
ISBN:	9781303227400

Pharmacological modulation of muscle-derived stem cells for the repair of ischemic and/or necrotic skeletal muscle.
Awadalla, Nancy Amin.

Pharmacological modulation of muscle-derived stem cells for the repair of ischemic and/or necrotic skeletal muscle. - 69 p.

Source: Masters Abstracts International, Volume: 52-01.

Thesis (M.S.)--California State University, Dominguez Hills, 2013.

Critical limb ischemia and Duchene muscular dystrophy are two devastating diseases that eventually result in necrosis and ischemia of skeletal muscle. Minorities, particularly African American women, are at a higher risk for critical limb ischemia for reasons unrelated to social status. The amputation and mortality rate of this disease are substantial. Duchene muscular dystrophy, however, is an X-linked recessive genetic disorder that affects young boys that eventually leads to their death in their early twenties. Ongoing clinical trials are using bone marrow cells and endometrial regenerative cells as a means of stimulating angiogenesis; however, efficiency of using these cells to repair necrotic myofibers is unknown. This study shows that pharmacological modulation of muscle-derived stem cells implanted into the gastrocnemius of an ischemic or dystrophic mouse model may in some cases stimulate angiogenesis and early muscle repair, as well as reduce fibrosis, but this is presumably counteracted by myostatin over-expression.

ISBN: 9781303227400Subjects--Topical Terms:

1017686
Biology, Cell.

Pharmacological modulation of muscle-derived stem cells for the repair of ischemic and/or necrotic skeletal muscle.
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100 1 $a Awadalla, Nancy Amin. $3 2102308
245 1 0 $a Pharmacological modulation of muscle-derived stem cells for the repair of ischemic and/or necrotic skeletal muscle.
300 $a 69 p.
500 $a Source: Masters Abstracts International, Volume: 52-01.
500 $a Adviser: Helen Chun.
502 $a Thesis (M.S.)--California State University, Dominguez Hills, 2013.
520 $a Critical limb ischemia and Duchene muscular dystrophy are two devastating diseases that eventually result in necrosis and ischemia of skeletal muscle. Minorities, particularly African American women, are at a higher risk for critical limb ischemia for reasons unrelated to social status. The amputation and mortality rate of this disease are substantial. Duchene muscular dystrophy, however, is an X-linked recessive genetic disorder that affects young boys that eventually leads to their death in their early twenties. Ongoing clinical trials are using bone marrow cells and endometrial regenerative cells as a means of stimulating angiogenesis; however, efficiency of using these cells to repair necrotic myofibers is unknown. This study shows that pharmacological modulation of muscle-derived stem cells implanted into the gastrocnemius of an ischemic or dystrophic mouse model may in some cases stimulate angiogenesis and early muscle repair, as well as reduce fibrosis, but this is presumably counteracted by myostatin over-expression.
590 $a School code: 0582.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Health Sciences, General. $3 1017817
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710 2 $a California State University, Dominguez Hills. $3 1017917
773 0 $t Masters Abstracts International $g 52-01(E).
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1523469