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Mechano-Chemical Model of Cancer Cel...

Wang, Jui-Hsien.

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Mechano-Chemical Model of Cancer Cell Invasion.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Mechano-Chemical Model of Cancer Cell Invasion./
Author:	Wang, Jui-Hsien.
Description:	63 p.
Notes:	Source: Masters Abstracts International, Volume: 52-02.
Contained By:	Masters Abstracts International52-02(E).
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1545270
ISBN:	9781303390449

Mechano-Chemical Model of Cancer Cell Invasion.
Wang, Jui-Hsien.

Mechano-Chemical Model of Cancer Cell Invasion. - 63 p.

Source: Masters Abstracts International, Volume: 52-02.

Thesis (M.S.)--University of California, San Diego, 2013.

90% of the cancer-inflicted mortality comes from the acquired metastatic ability. Metastatic cancer cells can physically travel through the extracellular matrix (ECM) by regulating enzymatic proteolysis. By colocalizing enzymes such as Matrix Metalloproteases (MMPs) at the invasion site, cancer cells actively degrade the ECM structures to promote the invasion efficiency. In this theoretical study, we propose a mechano-chemically coupled model to study this multiphysical phenomenon. We use the regular perturbation method to derive an analytical expression for the deformation field induced by cell-exert stresses on a nonlinear, inhomogeneous material. We then propose a chemical model that reflects the dynamics of the system, which includes the enzyme kinetics and enzyme diffusion. The mechanical and chemical models are coupled under the considerations that, (1) material stiffness is related to the concentration of the denaturized substrate constituent; (2) catalytic reaction is accelerated by the mechanical strain energy, as found in the recent single molecule assays. Using this model, we study a synthetic stress field that is consistent with the experimental observations. It is found that by coupling force to the degradation process, the dynamics of the system is significantly altered. We perform a parametrized study on mechanical forces, colocalized enzyme concentration, and the enzyme release pattern to study its individual effects on the invasion. Qualitatively, the study reveals the importance of each parameters on affecting the invasion efficiency from a rigorous physical and mathematical point of views.

ISBN: 9781303390449Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Mechano-Chemical Model of Cancer Cell Invasion.
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020 $a 9781303390449
035 $a (MiAaPQ)AAI1545270
035 $a AAI1545270
040 $a MiAaPQ $c MiAaPQ
100 1 $a Wang, Jui-Hsien. $3 2099852
245 1 0 $a Mechano-Chemical Model of Cancer Cell Invasion.
300 $a 63 p.
500 $a Source: Masters Abstracts International, Volume: 52-02.
500 $a Adviser: Juan Carlos del Alamo.
502 $a Thesis (M.S.)--University of California, San Diego, 2013.
520 $a 90% of the cancer-inflicted mortality comes from the acquired metastatic ability. Metastatic cancer cells can physically travel through the extracellular matrix (ECM) by regulating enzymatic proteolysis. By colocalizing enzymes such as Matrix Metalloproteases (MMPs) at the invasion site, cancer cells actively degrade the ECM structures to promote the invasion efficiency. In this theoretical study, we propose a mechano-chemically coupled model to study this multiphysical phenomenon. We use the regular perturbation method to derive an analytical expression for the deformation field induced by cell-exert stresses on a nonlinear, inhomogeneous material. We then propose a chemical model that reflects the dynamics of the system, which includes the enzyme kinetics and enzyme diffusion. The mechanical and chemical models are coupled under the considerations that, (1) material stiffness is related to the concentration of the denaturized substrate constituent; (2) catalytic reaction is accelerated by the mechanical strain energy, as found in the recent single molecule assays. Using this model, we study a synthetic stress field that is consistent with the experimental observations. It is found that by coupling force to the degradation process, the dynamics of the system is significantly altered. We perform a parametrized study on mechanical forces, colocalized enzyme concentration, and the enzyme release pattern to study its individual effects on the invasion. Qualitatively, the study reveals the importance of each parameters on affecting the invasion efficiency from a rigorous physical and mathematical point of views.
590 $a School code: 0033.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Biophysics, General. $3 1019105
650 4 $a Biology, Cell. $3 1017686
690 $a 0541
690 $a 0786
690 $a 0379
710 2 $a University of California, San Diego. $b Engineering Sciences (Mechanical Engineering). $3 1057970
773 0 $t Masters Abstracts International $g 52-02(E).
790 $a 0033
791 $a M.S.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1545270