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The Effects of Cigarette Smoking Dur...

Packingham, Kevin Donald.

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The Effects of Cigarette Smoking During Acute Alcohol Intoxication.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The Effects of Cigarette Smoking During Acute Alcohol Intoxication./
Author:	Packingham, Kevin Donald.
Description:	182 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.
Contained By:	Dissertation Abstracts International75-08B(E).
Subject:	Psychology, Cognitive. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3618549
ISBN:	9781303869259

The Effects of Cigarette Smoking During Acute Alcohol Intoxication.
Packingham, Kevin Donald.

The Effects of Cigarette Smoking During Acute Alcohol Intoxication. - 182 p.

Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.

Thesis (Ph.D.)--Washington University in St. Louis, 2014.

The consumption, and often abuse, of alcohol is frequently accompanied by cigarette smoking. Between eighty and ninety-five percent of alcoholics also smoke cigarettes, a rate more than four times higher than in the general population. The mechanisms underlying this association remain poorly understood. A general class of explanation is that smoking might affect the acutely intoxicating effects of alcohol. The relationships could take several forms, none of which is necessarily exclusive of another. These could include 1) synergism of effects, especially reward-related feelings of stimulation and positive affect, 2) additive effects, whereby the stimulating effects of nicotine could offset the depressant effects of alcohol, and 3) smoking-related desensitization to the effects of alcohol, by a mechanism of cross-tolerance.

ISBN: 9781303869259Subjects--Topical Terms:

1017810
Psychology, Cognitive.

The Effects of Cigarette Smoking During Acute Alcohol Intoxication.
LDR:03769nam a2200313 4500 001 1962907
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008 150210s2014 ||||||||||||||||| ||eng d
020 $a 9781303869259
035 $a (MiAaPQ)AAI3618549
035 $a AAI3618549
040 $a MiAaPQ $c MiAaPQ
100 1 $a Packingham, Kevin Donald. $3 2099045
245 1 4 $a The Effects of Cigarette Smoking During Acute Alcohol Intoxication.
300 $a 182 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.
500 $a Advisers: Deanna Barch; John Rohrbaugh.
502 $a Thesis (Ph.D.)--Washington University in St. Louis, 2014.
520 $a The consumption, and often abuse, of alcohol is frequently accompanied by cigarette smoking. Between eighty and ninety-five percent of alcoholics also smoke cigarettes, a rate more than four times higher than in the general population. The mechanisms underlying this association remain poorly understood. A general class of explanation is that smoking might affect the acutely intoxicating effects of alcohol. The relationships could take several forms, none of which is necessarily exclusive of another. These could include 1) synergism of effects, especially reward-related feelings of stimulation and positive affect, 2) additive effects, whereby the stimulating effects of nicotine could offset the depressant effects of alcohol, and 3) smoking-related desensitization to the effects of alcohol, by a mechanism of cross-tolerance.
520 $a The latter proposal, that smoking (i.e., nicotine) leads to cross-tolerance to alcohol, provides a guiding hypothesis for the research described here. Such a proposal is supported by an extensive body of evidence from animal studies that is consistent with an interpretation in terms of cross-tolerance between nicotine and alcohol, such that nicotine consumption diminishes sensitivity to the acute intoxicating effects of alcohol (on multiple measures). It has been hypothesized that the reduced sensitivity to the effects of alcohol could lead, in turn, to increased consumption and risk of addiction.
520 $a This research examines systematically the acute effects of moderate doses of alcohol and cigarette smoking alone and in combination, on several measures in a controlled laboratory environment. Principal focus is on measures of postural control, which are emphasized because of their known sensitivity to alcohol at moderate doses, and the role they have played in prior studies of individual differences in sensitivity to acute alcohol. Additionally, measures were obtained of subjective effects, oculomotor control, and cognitive functioning.
520 $a Eight participants (four female) were tested in four counterbalanced sessions involving alcohol only, cigarette only, alcohol with cigarette, and alcohol placebo only. During all sessions measures were obtained at baseline and at repeated intervals after dosing. Consistent with indications of cross-tolerance between alcohol and nicotine, smoking during the experimental sessions diminished selected effects of alcohol on key measures of postural and, to lesser extent, oculomotor control and subjective effects. The specific cognitive tasks chosen for study proved to be ineffective at detecting effects of alcohol or cigarette smoking. Results are discussed in terms of the physiological and psychological changes associated with the development of acute cross-tolerance, and other forms of interaction between alcohol and nicotine.
590 $a School code: 0252.
650 4 $a Psychology, Cognitive. $3 1017810
650 4 $a Psychology, Experimental. $3 517106
690 $a 0633
690 $a 0623
710 2 $a Washington University in St. Louis. $b Psychology. $3 1669827
773 0 $t Dissertation Abstracts International $g 75-08B(E).
790 $a 0252
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3618549