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EFFECTS OF ACUTE AND CHRONIC EXERCIS...

FREGOSI, RALPH FRANK, JR.

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EFFECTS OF ACUTE AND CHRONIC EXERCISE ON RESPIRATORY MUSCLE BIOCHEMISTRY AND BIOENERGETICS (DIAPHRAGM, METABOLISM, INTERCOSTALS, LACTATE, PLANTARIS).

Record Type:	Language materials, printed : Monograph/item
Title/Author:	EFFECTS OF ACUTE AND CHRONIC EXERCISE ON RESPIRATORY MUSCLE BIOCHEMISTRY AND BIOENERGETICS (DIAPHRAGM, METABOLISM, INTERCOSTALS, LACTATE, PLANTARIS)./
Author:	FREGOSI, RALPH FRANK, JR.
Description:	211 p.
Notes:	Source: Dissertation Abstracts International, Volume: 47-01, Section: B, page: 9000.
Contained By:	Dissertation Abstracts International47-01B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8601098

EFFECTS OF ACUTE AND CHRONIC EXERCISE ON RESPIRATORY MUSCLE BIOCHEMISTRY AND BIOENERGETICS (DIAPHRAGM, METABOLISM, INTERCOSTALS, LACTATE, PLANTARIS).
FREGOSI, RALPH FRANK, JR.

EFFECTS OF ACUTE AND CHRONIC EXERCISE ON RESPIRATORY MUSCLE BIOCHEMISTRY AND BIOENERGETICS (DIAPHRAGM, METABOLISM, INTERCOSTALS, LACTATE, PLANTARIS). - 211 p.

Source: Dissertation Abstracts International, Volume: 47-01, Section: B, page: 9000.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 1985.

The purpose of this thesis was to determine if changes in respiratory muscle metabolites associated with skeletal muscle fatigue occur during the physiologic state of muscular exercise.Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

EFFECTS OF ACUTE AND CHRONIC EXERCISE ON RESPIRATORY MUSCLE BIOCHEMISTRY AND BIOENERGETICS (DIAPHRAGM, METABOLISM, INTERCOSTALS, LACTATE, PLANTARIS).
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100 1 $a FREGOSI, RALPH FRANK, JR. $3 2098599
245 1 0 $a EFFECTS OF ACUTE AND CHRONIC EXERCISE ON RESPIRATORY MUSCLE BIOCHEMISTRY AND BIOENERGETICS (DIAPHRAGM, METABOLISM, INTERCOSTALS, LACTATE, PLANTARIS).
300 $a 211 p.
500 $a Source: Dissertation Abstracts International, Volume: 47-01, Section: B, page: 9000.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 1985.
520 $a The purpose of this thesis was to determine if changes in respiratory muscle metabolites associated with skeletal muscle fatigue occur during the physiologic state of muscular exercise.
520 $a Rats exercised on a treadmill at a variety of intensities 40-100% of maximal oxygen consumption ((')VO(,2) max) and durations (3-60 minutes) in normoxia, and also to exhaustion (24 (+OR-) 10 minutes) in acute hypoxia (FIO(,2) = 0.12). Rapidly frozen diaphragm and intercostal muscles from diethyl ether anesthetized rats were compared to the plantaris locomotor muscle.
520 $a Arterial blood gas studies revealed that marked alveolar hyperventilation occurred during all exercise conditions studied, particularly in hypoxic exercise where CaO(,2) fell 30% and PaCO(,2) fell to 22 mm Hg.
520 $a During all normoxic exercise conditions ATP and CP were maintained at resting levels, except at 100% (')VO(,2) max, where CP fell slightly in diaphragm and plantaris. Plantaris glycogen fell and lactate (LA) rose as exercise intensity increased, suggesting net LA production. In respiratory muscles LA rose but glycogenolysis did not occur, implying uptake of LA from blood. G6P increased with exercise only in diaphragm, suggesting that the absence of glycogenolysis was secondary to allosteric inhibition of glycogen phosphorylase b.
520 $a During hypoxic exercise, plantaris glycogenolysis was potentiated and respiratory muscles used (TURN)50% of their glycogen stores. LA increased as a function of glycogen loss in all three muscles, suggesting that they all produced LA under these conditions.
520 $a Eight weeks of endurance training increased whole body (')VO(,2) max 13% and plantaris muscle oxidative capacity increased 23-36% due to a 24-63% increase in mitochondrial mass (MM). In contrast, training had no effect on diaphragm aerobic capacity; however, aerobic capacity and MM in non-trained diaphragm was 2-3 fold that in non-trained plantaris.
520 $a I conclude that respiratory muscles, particularly the diaphragm, are resistant to biochemical fatigue during exercise. This is due to a very large aerobic capacity and MM which allows a greater use of blood borne substrates, thereby delaying the onset of glycogenolysis and lactate production.
590 $a School code: 0262.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Education, Physical. $3 1018000
690 $a 0433
690 $a 0523
710 2 $a The University of Wisconsin - Madison. $3 626640
773 0 $t Dissertation Abstracts International $g 47-01B.
790 $a 0262
791 $a Ph.D.
792 $a 1985
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8601098