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Magnetic Resonance Imaging with Hype...

The University of Wisconsin - Madison., Medical Physics.

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Magnetic Resonance Imaging with Hyperpolarized 13C Contrast Agents.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Magnetic Resonance Imaging with Hyperpolarized 13C Contrast Agents./
Author:	Gordon, Jeremy W.
Description:	181 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-03(E), Section: B.
Contained By:	Dissertation Abstracts International75-03B(E).
Subject:	Health Sciences, Radiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3603767
ISBN:	9781303585302

Magnetic Resonance Imaging with Hyperpolarized 13C Contrast Agents.
Gordon, Jeremy W.

Magnetic Resonance Imaging with Hyperpolarized 13C Contrast Agents. - 181 p.

Source: Dissertation Abstracts International, Volume: 75-03(E), Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2013.

Hyperpolarized 13C substrates offer the potential to non-invasively image metabolism and enzymatic activity. However, hyperpolarization introduces a number of difficulties, and imaging is hampered by non-equilibrium magnetization and the need for spectral encoding. There is therefore a need for fast and RF efficient spectral imaging techniques. This work presents a number of new methods that can be used to improve polarization, increase RF efficiency and improve modeling accuracy in hyperpolarized 13C experiments. In particular, a novel encoding and reconstruction algorithm is presented that can generate spatially and spectrally resolved images with a single RF excitation and echo time. This reconstruction framework increases data acquisition efficiency, enabling accelerated acquisition speed, preserved polarization, and/or improved temporal or spatial resolution. Overall, the methods enumerated in this dissertation have the potential to improve modeling accuracy and to mitigate the conventional tradeoffs between SNR, spatial resolution, and temporal resolution that govern image quality in hyperpolarized 13C experiments.

ISBN: 9781303585302Subjects--Topical Terms:

1019076
Health Sciences, Radiology.

Magnetic Resonance Imaging with Hyperpolarized 13C Contrast Agents.
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020 $a 9781303585302
035 $a (MiAaPQ)AAI3603767
035 $a AAI3603767
040 $a MiAaPQ $c MiAaPQ
100 1 $a Gordon, Jeremy W. $3 2097833
245 1 0 $a Magnetic Resonance Imaging with Hyperpolarized 13C Contrast Agents.
300 $a 181 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-03(E), Section: B.
500 $a Adviser: Sean B. Fain.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2013.
520 $a Hyperpolarized 13C substrates offer the potential to non-invasively image metabolism and enzymatic activity. However, hyperpolarization introduces a number of difficulties, and imaging is hampered by non-equilibrium magnetization and the need for spectral encoding. There is therefore a need for fast and RF efficient spectral imaging techniques. This work presents a number of new methods that can be used to improve polarization, increase RF efficiency and improve modeling accuracy in hyperpolarized 13C experiments. In particular, a novel encoding and reconstruction algorithm is presented that can generate spatially and spectrally resolved images with a single RF excitation and echo time. This reconstruction framework increases data acquisition efficiency, enabling accelerated acquisition speed, preserved polarization, and/or improved temporal or spatial resolution. Overall, the methods enumerated in this dissertation have the potential to improve modeling accuracy and to mitigate the conventional tradeoffs between SNR, spatial resolution, and temporal resolution that govern image quality in hyperpolarized 13C experiments.
590 $a School code: 0262.
650 4 $a Health Sciences, Radiology. $3 1019076
650 4 $a Chemistry, General. $3 1021807
650 4 $a Physics, General. $3 1018488
690 $a 0574
690 $a 0485
690 $a 0605
710 2 $a The University of Wisconsin - Madison. $b Medical Physics. $3 2097834
773 0 $t Dissertation Abstracts International $g 75-03B(E).
790 $a 0262
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3603767