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Blue-green algae as a nutritional su...

Ginsberg, Donald Ian.

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Blue-green algae as a nutritional supplement: Evidence for effects on the circulation and function of immune cells in humans (Aphanizomenon flos-aqua).

Record Type:	Electronic resources : Monograph/item
Title/Author:	Blue-green algae as a nutritional supplement: Evidence for effects on the circulation and function of immune cells in humans (Aphanizomenon flos-aqua)./
Author:	Ginsberg, Donald Ian.
Description:	81 p.
Notes:	Source: Masters Abstracts International, Volume: 40-04, page: 0932.
Contained By:	Masters Abstracts International40-04.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ64359
ISBN:	061264359X

Blue-green algae as a nutritional supplement: Evidence for effects on the circulation and function of immune cells in humans (Aphanizomenon flos-aqua).
Ginsberg, Donald Ian.

Blue-green algae as a nutritional supplement: Evidence for effects on the circulation and function of immune cells in humans (Aphanizomenon flos-aqua). - 81 p.

Source: Masters Abstracts International, Volume: 40-04, page: 0932.

Thesis (M.Sc.)--McGill University (Canada), 2000.

Blue-green algae, historically consumed as a food source in certain native cultures, has more recently been promoted as a nutritional supplement for the general public. Several claims have been made regarding the consumption of blue-green algae. Such claims range from increased physical and mental energy to the treatment of neurological disorders and the enhancement of the immune system.

ISBN: 061264359XSubjects--Topical Terms:

1017835
Biology, Animal Physiology.

Blue-green algae as a nutritional supplement: Evidence for effects on the circulation and function of immune cells in humans (Aphanizomenon flos-aqua).
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100 1 $a Ginsberg, Donald Ian. $3 1953392
245 1 0 $a Blue-green algae as a nutritional supplement: Evidence for effects on the circulation and function of immune cells in humans (Aphanizomenon flos-aqua).
300 $a 81 p.
500 $a Source: Masters Abstracts International, Volume: 40-04, page: 0932.
500 $a Adviser: Gitte Jensen.
502 $a Thesis (M.Sc.)--McGill University (Canada), 2000.
520 $a Blue-green algae, historically consumed as a food source in certain native cultures, has more recently been promoted as a nutritional supplement for the general public. Several claims have been made regarding the consumption of blue-green algae. Such claims range from increased physical and mental energy to the treatment of neurological disorders and the enhancement of the immune system.
520 $a In order to determine whether the species of blue-green algae Aphanizomenon flos-aqua (AFA) has effects on immune cell circulation and function, 21 volunteers were involved in a crossover, double-blinded placebo-controlled study. Results reveal that two hours after AFA consumption, there was a generalized mobilization of lymphocytes and monocytes. This mobilization included increases in the CD3+, CD4+, and CD8+ T cell subsets, and of CD19+ B cells, in peripheral blood. In neither the CD4+ nor the CD8+ subsets however, were changes observed in the relative proportions of naive versus memory T cells. In addition, the relative proportions and absolute numbers of natural killer (NK) cells in peripheral blood were reduced after AFA consumption. This effect did not occur with polymorphonuclear (PMN) cells.
520 $a Using in vitro techniques to elucidate possible mechanisms of these in vivo observations, we have found that AFA binds to the L-selectin molecule on lymphocytes and PMNs. Furthermore, it does not directly activate lymphocytes, as evaluated by tyrosine phosphorylation, and by proliferative activity. Similarly, AFA does not induce reactive oxygen species formation in PMNs in vitro, and appears to slightly reduce the phagocytic activity of PMNs harvested from volunteers 2 hours post-consumption (ex-vivo).
520 $a Further studies are required to determine the components of AFA that are responsible for these phenomena. By altering the circulation of specific leukocyte subsets however, AFA represents a novel approach to modulating immune surveillance. Such an approach may have implications in the treatment and prevention of infection, cancer, and immunodeficiency states.
590 $a School code: 0781.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Health Sciences, Nutrition. $3 1017801
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690 $a 0982
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710 2 0 $a McGill University (Canada). $3 1018122
773 0 $t Masters Abstracts International $g 40-04.
790 1 0 $a Jensen, Gitte, $e advisor
790 $a 0781
791 $a M.Sc.
792 $a 2000
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ64359