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Magnetic resonance imaging analysis ...

Keener, Ronald Nixon, III.

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Magnetic resonance imaging analysis and continuum mechanics modeling of chromatography column packing and scale-up.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Magnetic resonance imaging analysis and continuum mechanics modeling of chromatography column packing and scale-up./
Author:	Keener, Ronald Nixon, III.
Description:	175 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1369.
Contained By:	Dissertation Abstracts International64-03B.
Subject:	Engineering, Chemical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3083089

Magnetic resonance imaging analysis and continuum mechanics modeling of chromatography column packing and scale-up.
Keener, Ronald Nixon, III.

Magnetic resonance imaging analysis and continuum mechanics modeling of chromatography column packing and scale-up. - 175 p.

Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1369.

Thesis (Ph.D.)--University of Virginia, 2003.

As biopharmaceuticals are becoming an increasing fraction of new therapeutic candidates, and as the scale of many of these processes continues to increase, there is a growing need for packing procedures which can be scaled while preserving column elution profiles and structural stability. Toward the development of rigorous and practical model descriptions of the column packing process, we have applied theoretical approaches from the continuum mechanics of solids to describe column packing and scale-up effects. To elucidate important factors in structural stability and elution profiles, we used magnetic resonance imaging (MRI) to provide in situ porosity maps and concentration profiles.Subjects--Topical Terms:

1018531
Engineering, Chemical.

Magnetic resonance imaging analysis and continuum mechanics modeling of chromatography column packing and scale-up.
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008 130614s2003 eng d
035 $a (UnM)AAI3083089
035 $a AAI3083089
040 $a UnM $c UnM
100 1 $a Keener, Ronald Nixon, III. $3 1952710
245 1 0 $a Magnetic resonance imaging analysis and continuum mechanics modeling of chromatography column packing and scale-up.
300 $a 175 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1369.
500 $a Adviser: Erik J. Fernandez.
502 $a Thesis (Ph.D.)--University of Virginia, 2003.
520 $a As biopharmaceuticals are becoming an increasing fraction of new therapeutic candidates, and as the scale of many of these processes continues to increase, there is a growing need for packing procedures which can be scaled while preserving column elution profiles and structural stability. Toward the development of rigorous and practical model descriptions of the column packing process, we have applied theoretical approaches from the continuum mechanics of solids to describe column packing and scale-up effects. To elucidate important factors in structural stability and elution profiles, we used magnetic resonance imaging (MRI) to provide in situ porosity maps and concentration profiles.
520 $a Our modeling efforts showed that a Cauchy elasticity based model can quantitatively describe column packing, including the effects of scale-up. The model was evaluated for both components of packing procedures: mechanical compression (e.g. by a headpiece) and flow-induced consolidation. The key factor in the model's success was accounting for dependence of media rigidity on the method of packing.
520 $a Using MRI, we found that the slope of axial porosity profiles is an important factor pertaining to the structural stability of a bed. We found that the surface chemistry and rigidity of media seem to influence the broadness and asymmetry of elution profiles. Sephadex G75, a model non-rigid resin, was prone to peak broadening as a result of gradual radial variation in porosity spanning about a column diameter. In contrast, Phenyl Sepharose 6FF, a representative hydrophobic interaction resin was prone to a leading edge feature that was related to a sharp porosity increase adjacent to the column wall.
590 $a School code: 0246.
650 4 $a Engineering, Chemical. $3 1018531
650 4 $a Chemistry, Analytical. $3 586156
690 $a 0542
690 $a 0486
710 2 0 $a University of Virginia. $3 645578
773 0 $t Dissertation Abstracts International $g 64-03B.
790 1 0 $a Fernandez, Erik J., $e advisor
790 $a 0246
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3083089