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Imaging skin pathologies with polari...

Ramella-Roman, Jessica C.

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Imaging skin pathologies with polarized light: Empirical and theoretical studies.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Imaging skin pathologies with polarized light: Empirical and theoretical studies./
Author:	Ramella-Roman, Jessica C.
Description:	280 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5972.
Contained By:	Dissertation Abstracts International64-12B.
Subject:	Biophysics, Medical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3116955

Imaging skin pathologies with polarized light: Empirical and theoretical studies.
Ramella-Roman, Jessica C.

Imaging skin pathologies with polarized light: Empirical and theoretical studies. - 280 p.

Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5972.

Thesis (Ph.D.)--OGI School of Science & Engineering, 2004.

The use of polarized light imaging can facilitate the determination of skin cancer borders before a Mohs surgery procedure. Linearly polarized light that illuminates the skin is backscattered by superficial layers where cancer often arises and is randomized by the collagen fibers. The superficially backscattered light can be distinguished from the diffused reflected light using a detector analyzer that is sequentially oriented parallel and perpendicular to the source polarization. A polarized image pol = parallel - perpendicular / parallel + perpendicular is generated. This image has a higher contrast to the superficial skin layers than simple total reflectance images. Pilot clinical trials were conducted with a small hand-held device for the accumulation of a library of lesions to establish the efficacy of polarized light imaging in vivo. It was found that melanoma exhibits a high contrast to polarized light imaging as well as basal and sclerosing cell carcinoma. Mechanisms of polarized light scattering from different tissues and tissue phantoms were studied in vitro. Parameters such as depth of depolarization (DOD), retardance, and birefringence were studied in theory and experimentally. Polarized light traveling through different tissues (skin, muscle, and liver) depolarized after a few hundred microns. Highly birefringent materials such as skin (DOD = 300 mum 696nm) and muscle (DOD = 370 mum 696nm) depolarized light faster than less birefringent materials such as liver (DOD = 700 mum 696nm). Light depolarization can also be attributed to scattering. Three Monte Carlo programs for modeling polarized light transfer into scattering media were implemented to evaluate these mechanisms. Simulations conducted with the Monte Carlo programs showed that small diameter spheres have different mechanisms of depolarization than larger ones. The models also showed that the anisotropy parameter g strongly influences the depolarization mechanism. (Abstract shortened by UMI.)Subjects--Topical Terms:

1017681
Biophysics, Medical.

Imaging skin pathologies with polarized light: Empirical and theoretical studies.
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245 1 0 $a Imaging skin pathologies with polarized light: Empirical and theoretical studies.
300 $a 280 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5972.
500 $a Supervisor: Steven L. Jacques.
502 $a Thesis (Ph.D.)--OGI School of Science & Engineering, 2004.
520 $a The use of polarized light imaging can facilitate the determination of skin cancer borders before a Mohs surgery procedure. Linearly polarized light that illuminates the skin is backscattered by superficial layers where cancer often arises and is randomized by the collagen fibers. The superficially backscattered light can be distinguished from the diffused reflected light using a detector analyzer that is sequentially oriented parallel and perpendicular to the source polarization. A polarized image pol = parallel - perpendicular / parallel + perpendicular is generated. This image has a higher contrast to the superficial skin layers than simple total reflectance images. Pilot clinical trials were conducted with a small hand-held device for the accumulation of a library of lesions to establish the efficacy of polarized light imaging in vivo. It was found that melanoma exhibits a high contrast to polarized light imaging as well as basal and sclerosing cell carcinoma. Mechanisms of polarized light scattering from different tissues and tissue phantoms were studied in vitro. Parameters such as depth of depolarization (DOD), retardance, and birefringence were studied in theory and experimentally. Polarized light traveling through different tissues (skin, muscle, and liver) depolarized after a few hundred microns. Highly birefringent materials such as skin (DOD = 300 mum 696nm) and muscle (DOD = 370 mum 696nm) depolarized light faster than less birefringent materials such as liver (DOD = 700 mum 696nm). Light depolarization can also be attributed to scattering. Three Monte Carlo programs for modeling polarized light transfer into scattering media were implemented to evaluate these mechanisms. Simulations conducted with the Monte Carlo programs showed that small diameter spheres have different mechanisms of depolarization than larger ones. The models also showed that the anisotropy parameter g strongly influences the depolarization mechanism. (Abstract shortened by UMI.)
590 $a School code: 1401.
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Physics, Optics. $3 1018756
650 4 $a Engineering, Biomedical. $3 1017684
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