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Imaging the microcirculation with hi...

Goertz, David Eric.

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Imaging the microcirculation with high-frequency ultrasound.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Imaging the microcirculation with high-frequency ultrasound./
Author:	Goertz, David Eric.
Description:	180 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1652.
Contained By:	Dissertation Abstracts International64-04B.
Subject:	Biophysics, Medical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ78045
ISBN:	0612780457

Imaging the microcirculation with high-frequency ultrasound.
Goertz, David Eric.

Imaging the microcirculation with high-frequency ultrasound. - 180 p.

Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1652.

Thesis (Ph.D.)--University of Toronto (Canada), 2003.

Quantitative information about microvascular morphology and hemodynamics is of fundamental importance to the study of normal tissue development and function as well as in examining disease processes, such as cancer, glaucoma, and diabetes. In this thesis, high frequency (>20 MHz) ultrasound flow imaging is investigated as a technique for non-invasively assessing the spatial distribution of blood flow in the microcirculation with a resolution on the order of 50--100 microns. The development and evaluation of novel 20--50 MHz discretely and continuously scanned flow imaging systems are described. System design emphasised sensitivity to microvascular flow and enabled the examination of a wide range of velocities (<1 mm/s to 25 mm/s) for tissue volumes of sizes up to 10 mm laterally and 5--10 mm in depth. By integrating previously reported pulsed-wave Doppler instrumentation, there was a capability of operating in either imaging or pulsed-wave Doppler mode. The implications and trade-offs of using the faster continuous scanning approach in the context of microvascular flow imaging are identified and investigated. In vivo validation experiments conducted at 50 MHz in the mouse ear demonstrated the detection of flow in vessels down to 15--20 mum in diameter with flow velocities on the order of millimeters per second. In vivo 3D validation experiments using the mouse ear demonstrated the ability to follow branching patterns of closely spaced microvessels from 30 mum to 100 mum in diameter. Experiments conducted on mouse tumours successfully imaged complex flow patterns in the tumour microcirculation. The application of these techniques to quantitatively monitor the effects of antivascular therapy on superficial tumours was demonstrated and correlated with independent perfusion staining results. Experimental work also showed that nonlinear scattering can be generated from microbubbles at high frequencies, suggesting the possibility of implementing nonlinear contrast imaging at high frequencies. The work of this thesis has contributed to demonstrating that high frequency ultrasound flow imaging is a unique and sensitive tool for assessing the microcirculation of superficial tissues.

ISBN: 0612780457Subjects--Topical Terms:

1017681
Biophysics, Medical.

Imaging the microcirculation with high-frequency ultrasound.
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100 1 $a Goertz, David Eric. $3 1951930
245 1 0 $a Imaging the microcirculation with high-frequency ultrasound.
300 $a 180 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1652.
500 $a Adviser: F. Stuart Foster.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2003.
520 $a Quantitative information about microvascular morphology and hemodynamics is of fundamental importance to the study of normal tissue development and function as well as in examining disease processes, such as cancer, glaucoma, and diabetes. In this thesis, high frequency (>20 MHz) ultrasound flow imaging is investigated as a technique for non-invasively assessing the spatial distribution of blood flow in the microcirculation with a resolution on the order of 50--100 microns. The development and evaluation of novel 20--50 MHz discretely and continuously scanned flow imaging systems are described. System design emphasised sensitivity to microvascular flow and enabled the examination of a wide range of velocities (<1 mm/s to 25 mm/s) for tissue volumes of sizes up to 10 mm laterally and 5--10 mm in depth. By integrating previously reported pulsed-wave Doppler instrumentation, there was a capability of operating in either imaging or pulsed-wave Doppler mode. The implications and trade-offs of using the faster continuous scanning approach in the context of microvascular flow imaging are identified and investigated. In vivo validation experiments conducted at 50 MHz in the mouse ear demonstrated the detection of flow in vessels down to 15--20 mum in diameter with flow velocities on the order of millimeters per second. In vivo 3D validation experiments using the mouse ear demonstrated the ability to follow branching patterns of closely spaced microvessels from 30 mum to 100 mum in diameter. Experiments conducted on mouse tumours successfully imaged complex flow patterns in the tumour microcirculation. The application of these techniques to quantitatively monitor the effects of antivascular therapy on superficial tumours was demonstrated and correlated with independent perfusion staining results. Experimental work also showed that nonlinear scattering can be generated from microbubbles at high frequencies, suggesting the possibility of implementing nonlinear contrast imaging at high frequencies. The work of this thesis has contributed to demonstrating that high frequency ultrasound flow imaging is a unique and sensitive tool for assessing the microcirculation of superficial tissues.
590 $a School code: 0779.
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Engineering, Biomedical. $3 1017684
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790 $a 0779
791 $a Ph.D.
792 $a 2003
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